FlyBase Allele Report: Dmel\Kdm5[JmjC.mut.UASp]

General Information

Symbol

Dmel\Kdm5^{JmjC.mut.UASp}

Species

D. melanogaster

Name

FlyBase ID

FBal0215596

Feature type

allele

Associated gene

Dmel\Kdm5

Associated Insertion(s)

Carried in Construct

P{UASp-Kdm5.JmjC.mut}

Key Links

Transgenic product class

missense_variant

(Secombe et al., 2007)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Secombe et al., 2007)

Mutagen

in vitro construct

(Secombe et al., 2007)

Progenitor genotype

Carried in construct

P{UASp-Kdm5.JmjC.mut}

Cytology

Description

Amino acid replacement: H637A.

(Secombe et al., 2007)

UASp regulatory sequences drive expression of full-length lid containing two point mutations in the demethylase domain.

(Secombe et al., 2007)

Amino acid replacement: E639A.

(Secombe et al., 2007)

Allele components

Component

Use(s)

Regulatory region(s)

UASp

binary expression system - regulatory region

Encoded product / tool

Kdm5

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile, with Scer\GAL4^Act.PU

(Li et al., 2010)

viable, with Scer\GAL4^Act.PU

(Li et al., 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

Females expressing lid^{JmjC.mut.Scer\UAS.P\T} under the control of Scer\GAL4^Act.PU do not lay eggs.

(Li et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Scer\GAL4^Act.PU/Kdm5^{JmjC.mut.UASp} is an enhancer of visible | adult stage | somatic clone - tissue specific phenotype of Kdm5^I1, hid^GMR.PG

(Herz and Bergmann, 2024)

Scer\GAL4^Act.PU/Kdm5^{JmjC.mut.UASp} is an enhancer of decreased size | adult stage | somatic clone - tissue specific phenotype of Kdm5^I1, hid^GMR.PG

(Herz and Bergmann, 2024)

Kdm5^{JmjC.mut.UASp}, Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Myc^UAS.cZa, Scer\GAL4^GMR.PF

(Li et al., 2010, Secombe et al., 2007)

Phenotype Manifest In

Enhancer of

Statement

Reference

Scer\GAL4^Act.PU/Kdm5^{JmjC.mut.UASp} is an enhancer of eye | somatic clone - tissue specific phenotype of Kdm5^I1, hid^GMR.PG

(Herz and Bergmann, 2024)

Kdm5^{JmjC.mut.UASp}, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Myc^UAS.cZa, Scer\GAL4^GMR.PF

(Li et al., 2010, Secombe et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of lid^{JmjC.mut.Scer\UAS.P\T} enhances the rough eye phenotype caused by expression of dm^Scer\UAS.cZa under the control of Scer\GAL4^GMR.PF.

(Secombe et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to rescue

Scer\GAL4^Act.PU/Kdm5^{JmjC.mut.UASp} fails to rescue Kdm5¹⁰⁴²⁴

(Li et al., 2010)

Comments

Expression of lid^{JmjC.mut.Scer\UAS.P\T} under the control of Scer\GAL4^Act.PU does not rescue the lethality of lid¹⁰⁴²⁴ homozygotes.

(Li et al., 2010)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Kdm5^{JmjC.mut.UASp}

lid^{JmjC.mut.Scer\UAS.P\T}

lid^{JmjC.mut.UASp}

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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