FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mir-8Δ1
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General Information
Symbol
Dmel\mir-8Δ1
Species
D. melanogaster
Name
FlyBase ID
FBal0216286
Feature type
allele
Associated gene
Dmel\mir-8
Associated Insertion(s)
TI{TI}mir-8Δ1
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
recombination
(Karres et al., 2007)
I-SceI
(Karres et al., 2007)
FLPase
(Karres et al., 2007)
gene targeting by homologous recombination
(Karres et al., 2007)
Progenitor genotype
Associated Insertion(s)
TI{TI}mir-8Δ1
Cytology
Description

A 400bp fragment spanning the mir-8 hairpin has been replaced by a w+* marker.

(Karres et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Total bouton number at the neuromuscular junction is significantly decreased compared to controls in mir-8Δ1/mir-8Δ2 larvae.

      (Nesler et al., 2013)

      Female mir-8jk22/mir-8Δ1 flies exhibit alterations in the spatial pigmentation pattern of the dorsal abdomen, most evident in the A6 segment. At 25[o]C, rather than having pigmentation throughout most of the segment as is seen in wild type flies, the pigmentation in mutant females is widest at the dorsal midline and tapers off laterally.

      Female mir-8Δ1/Df(2R)ED2747 flies exhibit alterations in the spatial pigmentation pattern of the dorsal abdomen, most evident in the A6 segment. At 25[o]C, rather than having pigmentation throughout most of the segment as is seen in wild type flies, the pigmentation in mutant females is widest at the dorsal midline and tapers off laterally.

      (Kennell et al., 2012)

      mir-8Δ1/mir-8Δ2 and mir-8Δ1/Df(2R)mir-8Δ3 animals show reduced survival during pupal and early adult stages, either failing to emerge from the pupal case or dying within the first 24 hours of eclosion.

      mir-8Δ1/mir-8Δ2 and mir-8Δ1/Df(2R)mir-8Δ3 adult escapers often have wing defects (the wings are not properly unfolded) or leg defects.

      (Karres et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      miR-8Δ1
      (Nesler et al., 2013)
      mir-8Δ1
      (Kennell et al., 2012, Karres et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)