FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\DysGE20705
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General Information
Symbol
Dmel\DysGE20705
Species
D. melanogaster
Name
FlyBase ID
FBal0216502
Feature type
allele
Associated gene
Dmel\Dys
Associated Insertion(s)
P{EP}DysGE20705
Carried in Construct
Also Known As
GE20705
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{EP}DysGE20705
    Cytology
    Description

    P{EP}DysGE20705 is present 250bp upstream of the Dys Dp186 isoform initiator ATG.

    (van der Plas et al., 2006)
    Allele components
    Component
    Use(s)
    Inserted element
    P{EP}
    Regulatory region(s)
    UAS
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Quantal content is approximately 50-65% higher in DysGE20705 mutants compared to wild-type. The frequency of spontaneous neurotransmitter release is elevated approximately 35-50% in DysGE20705 mutants.

        DysE6/DysGE20705 trans-heterozygotes exhibit an increase in EJP amplitude compared to controls when evoked by nerve stimulation at 0.3Hz. Quantal content is also significantly higher in DysE6/DysGE20705 trans-heterozygotes compared to wild-type.

        DysGE20705/+ heterozygotes exhibit an increase in EJP amplitude compared to controls when evoked by nerve stimulation at 0.3Hz. Quantal content is also significantly higher in DysGE20705/+ trans-heterozygotes compared to wild-type.

        Synaptic boutons in DysGE20705 appear slightly more elongated than in controls. The areas of the bouton occupied by vesicles is increase in DysGE20705 mutants compared with wild-type. The number of active zones with a T-bar relative to the total number of active zones is significantly increased in DysGE20705 mutants by approximately two-fold, whereas the overall number of active zones does not increase.

        (van der Plas et al., 2006)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        DysGE20705
        detGE20705
        dysGE20705
        (van der Plas et al., 2006)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)