FlyBase Allele Report: Hsap\YAP1[S127A.UAS]

General Information

Symbol

Hsap\YAP1^S127A.UAS

Species

H. sapiens

Name

FlyBase ID

FBal0216674

Feature type

allele

Associated gene

Hsap\YAP1

Associated Insertion(s)

Carried in Construct

P{UAS-YAP.S127A}

Also Known As

YAP^S127A

Key Links

Transgenic product class

missense_variant

(Dong et al., 2007)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Dong et al., 2007)

Mutagen

in vitro construct

(Dong et al., 2007)

Progenitor genotype

Carried in construct

P{UAS-YAP.S127A}

Cytology

Description

Amino acid replacement: S127A.

(Dong et al., 2007)

UAS regulatory sequences drive expression of a mutated form of Hsap\YAP1.

(Dong et al., 2007)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\YAP1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage, with Scer\GAL4^GMR.PF

(Koontz et al., 2013)

visible, with Scer\GAL4^GMR.PF

(Dong et al., 2007)

visible | adult stage, with Scer\GAL4^GMR.PF

(Koontz et al., 2013)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PF

(Koontz et al., 2013, Dong et al., 2007)

Detailed Description

Statement

Reference

Flies expressing Hsap\YAP1^{S127A.Scer\UAS} under the control of Scer\GAL4^GMR.PF exhibit eye overgrowth.

(Koontz et al., 2013)

Expression of Hsap\YAP1^{S127A.Scer\UAS} under the control of Scer\GAL4^GMR.PF results in a dramatic increase in eye size.

(Dong et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Hsap\YAP1^S127A.UAS, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible | partially by Hsap\VGLL4^UAS.cKa, Scer\GAL4^GMR.PF

(Koontz et al., 2013)

Hsap\YAP1^S127A.UAS, Scer\GAL4^GMR.PF has abnormal size | adult stage phenotype, suppressible | partially by Hsap\VGLL4^UAS.cKa, Scer\GAL4^GMR.PF

(Koontz et al., 2013)

Phenotype Manifest In

Suppressed by

Statement

Reference

Hsap\YAP1^S127A.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible | partially by Hsap\VGLL4^UAS.cKa, Scer\GAL4^GMR.PF

(Koontz et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\VGLL4^Scer\UAS.cKa significantly suppresses the eye overgrowth seen when Hsap\YAP1^{S127A.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PF.

(Koontz et al., 2013)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hsap\YAP1^{S127A.Scer\UAS}

Hsap\YAP1^S127A.UAS

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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