FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\tombGS12862
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General Information
Symbol
Dmel\tombGS12862
Species
D. melanogaster
Name
FlyBase ID
FBal0216718
Feature type
allele
Associated gene
Dmel\tomb
Associated Insertion(s)
P{GSV6}tombGS12862
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GSV6}tombGS12862
    Cytology
    Description

    The P{GSV6}tombGS12862 insertion maps within both tomb and Cap-D3 (overlapping genes on opposite strands). The insertion is within codon 174 of tomb and within the Cap-D3 3'UTR. The male sterility phenotype of the P{GSV6}tombGS12862 insertion is due to an effect on tomb and not Cap-D3 as transheterozygotes of P{GSV6}tombGS12862 with Cap-D3EY00456 are male fertile.

    (Jiang et al., 2007)
    Allele components
    Component
    Use(s)
    Inserted element
    P{GSV6}
    Regulatory region(s)
    UASt
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In

        nuclear chromosome & primary spermatocyte

        (Jiang et al., 2007)

        testis

        (Jiang et al., 2007)
        Detailed Description
        Statement
        Reference

        Mutant testes contain morphologically normal stages of spermatogenesis, up to and including mature primary spermatocytes, but no meiotic division or post-meiotic stages.

        Chromosomes in mutant primary spermatocytes are apposed to the nuclear envelope (as occurs in wild-type primary spermatocytes), but they are fuzzier and less well defined than in wild type.

        (Jiang et al., 2007)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Excision of the insertion in tombGS12862 can result in full reversion of the mutant phenotype.

        (Jiang et al., 2007)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        tombGS12862
        (Reinhardt and Jones, 2013)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)