FB2026_02 , released June 18, 2026
Allele: Dmel\mmyJ1201
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General Information
Symbol
Dmel\mmyJ1201
Species
D. melanogaster
Name
FlyBase ID
FBal0216801
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
    Nature of the Allele
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
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    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
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    Modifiers Based on Experimental Evidence ( 0 )
    Disease
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    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Stage 16 mmyJ1201 homozygous embryos have slightly fewer midline glial cells than wild-type (an average of 2.5/neuromere compared to a wild-type average of 3), and those present are misplaced. The longitudinal connectives are thinner and closer to the midline and segmental commissures are located closer together. There are severe fasciculation defects at the midline with many axons being much more loosely fasciculated than in wild-type. Fasciculation of axons is also much looser in the peripheral nervous system and chordotonal organ clusters are disorganised.

    More than 90% of stage 16 mmyJ1201 embryos have a dorsal hole, this falls to about 50% in mutant larvae. These embryos and larvae also exhibit a weak general differentiation of the cuticle. During dorsal closure, leading edge cells are more rounded than in wild-type.

    Eyes consisting mainly of mmyJ1201 homozygous somatic clone cells (generated using Scer\FLP1ey.PN with Scer\FRT) are small with irregularly spaced ommatidia. In eye discs of this genotype, fewer photoreceptor cells differentiate posterior to the furrow and those that do form are irregularly spaced.

    External Data
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    Additional Comments
    Genetic Interactions
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    Xenogenetic Interactions
    Statement
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    Complementation and Rescue Data
    Comments

    Failure of dorsal closure in mmyJ1201 homozygous embryos is not rescued by JraAsp.Scer\UAS with Scer\GAL469B or Scer\GAL4pnr-MD237.

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    Mutant
    Wild-type
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    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (3)
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    Secondary FlyBase IDs
      References (1)