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General Information
Symbol
Dmel\baf3A.UASp
Species
D. melanogaster
Name
FlyBase ID
FBal0216873
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASp regulatory sequences drive expression of a non-phosphorylatable form of baf (three potential phosphorylation sites have been mutated to Ala residues, changes are S2A, T4A and S5A).

Amino acid replacement: S?A.

Amino acid replacement: T?A.

UASp regulatory sequences drive expression of a mutated form of baf (three potential phosphorylation sites have been mutated to Ala residues).

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of baf3A.Scer\UAS.P\T under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 results in severe condensation defects and amorphous or undercondensed chromosomes in mature oocytes.

Expression of baf3A.Scer\UAS.P\T under the control of Scer\GAL4167Y results in chromosome condensation defects (undercondensed chromosomes) in mitotic cells in the central nervous system, the frequency of mitotic cells (phospho-histone H3-positive) is significantly increased compared to wild-type.

Expression of baf3A.Scer\UAS.P\T under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 disrupts karyosome morphology in the oocyte; the karyosome often loses its spherical shape and becomes more extended, and the chromosomes often form extensive contact with the nuclear envelope.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
baf3A.Scer\UAS.P\T
baf3A.UASp
Name Synonyms
Secondary FlyBase IDs
    References (3)