Homozygous embryos hatch normally, but the first instar larvae appear sick, showing very little locomotion or feeding activity, and they die soon after hatching.

uri^110b/Df(2R)Px2 pharate adult males which have been partially rescued by expression of uri^{Scer\UAS.T:Hsap\MYC,T:Zzzz\His6} under the control of Scer\GAL4^arm.PS (these animals are essentially only rescued in the soma) have much smaller testes than controls. The testes contain a few apparently normal spermatogonia and spermatocytes and some elongated spermatids. Post-meiotic spermatids usually have an abnormal morphology, although a small number of motile sperm are sometimes seen. In addition to the healthy cells, the mutant testes are full of dying cells and debris from dead cells. The testes of somatically rescued larvae have high levels of TUNEL labelling, indicating that the cells contain damaged DNA.

uri^110b/Df(2R)Px2 pharate adult females which have been partially rescued by expression of uri^{Scer\UAS.T:Hsap\MYC,T:Zzzz\His6} under the control of Scer\GAL4^arm.PS have smaller ovaries than normal and the germaria are thinner than in wild type. Most ovarioles lack well defined stage 1 and later egg chambers.

uri^110b/Df(2R)Px2 pharate adult males which have been partially rescued by expression of uri^{Scer\UAS.T:Hsap\MYC,T:Zzzz\His6} under the control of both Scer\GAL4^arm.PS and Scer\GAL4^{bam.T:Hsim\VP16} have smaller testes than wild type. Many differentiating spermatid bundles and numerous motile sperm are seen. However, only a few cysts of spermatogonia and spermatocytes are seen and post-meiotic spermatids are located much closer to the apical tip of the testis than is normal.