FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Hip14ex11
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General Information
Symbol
Dmel\Hip14ex11
Species
D. melanogaster
Name
FlyBase ID
FBal0217340
Feature type
allele
Associated gene
Dmel\Hip14
Associated Insertion(s)
Carried in Construct
Also Known As
dHIP14ex11
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Stowers and Isacoff, 2007)
Mutagen
P-element activity
(Stowers and Isacoff, 2007)
Progenitor genotype
P{EPgy2}Hip14EY09853
(Stowers and Isacoff, 2007)
Cytology
Description

Imprecise excision of the P{EPgy2}Hip14EY09853 insertion, resulting in a deletion within the Hip14 gene that removes sequences encoding the translation start codon and the first 203 amino acids of the predicted protein.

(Stowers and Isacoff, 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The electroretinograms (ERGs) of flies in which the eyes are composed of homozygous tissue are abnormal; they lack the on and off transients (synaptic components of the ERG), while the slow phototransduction component is essentially normal. The external morphology of and photoreceptor axon development in homozygous eyes appears normal.

      Throughout larval development, zygotic mutants show normal and vigorous foraging behaviour with no discernible developmental delay. Homozygous and hemizygous animals dissected out of their pupal cases on the day that their heterozygous siblings eclose appear fully developed and are clearly alive, but are weak, uncoordinated and cannot stand upright. The electroretinograms of these pharate adults are indistinguishable from those of flies in which the eyes are composed of homozygous tissue.

      Homozygous mutants derived from females carrying homozygous germline clones show lethality during the first larval instar. These larvae hatch without a developmental delay from their egg case and have a normal appearance, but are sluggish and feed very little.

      (Stowers and Isacoff, 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The electroretinogram defects of flies in which the eyes are composed of homozygous Hip14ex11 tissue are rescued by expression of Hsap\ZDHHC17Scer\UAS.T:Avic\GFP under the control of Scer\GAL4ninaE.PT.

      (Stowers and Isacoff, 2007)
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hip14ex11
      (Porcellato et al., 2022)
      dHIP14ex11
      (Kim et al., 2024, Stowers and Isacoff, 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)