FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Frq1RNAi.UAS
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General Information
Symbol
Dmel\Frq1RNAi.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0217376
Feature type
allele
Associated gene
Dmel\Frq1
Associated Insertion(s)
Carried in Construct
P{UAS-Frq.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Romero-Pozuelo et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Romero-Pozuelo et al., 2007)
Mutagen
in vitro construct
(Romero-Pozuelo et al., 2007)
Progenitor genotype
Carried in construct
P{UAS-Frq.RNAi}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat consisting of a 5kb genomic fragment containing exons 3 through to the beginning of exon 8 of Frq1 followed by a 400bp cDNA fragment of Frq1 in reverse orientation.

(Romero-Pozuelo et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Frq1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Larvae co-expressing Frq2DN.Scer\UAS, Frq1DN.Scer\UAS and Frq1dsRNA.Scer\UAS under the control of Scer\GAL4D42 show an increase in the number of type 1s boutons at the larval neuromuscular junction, while the number of type 1b boutons is not significantly affected.

      The amplitude of the evoked excitatory junctional potential (EJP) at the neuromuscular junction is not significantly different from wild type in larvae expressing Frq1dsRNA.Scer\UAS under the control of Scer\GAL4D42 or Scer\GAL4elav-C155. The amplitude and frequency of spontaneous mEJPs is not affected in these flies. Quantal content of type 1b and type 1s boutons is unaffected.

      (Romero-Pozuelo et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      The P{UAS-Frq.RNAi} construct attenuates the expression of both the Frq1 and Frq2 genes.

      (Romero-Pozuelo et al., 2007)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Frq1RNAi.UAS
      Frq1dsRNA.Scer\UAS
      Frq1dsRNA.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)