FlyBase Allele Report: Dmel\Mical[K1496]

General Information

Symbol

Dmel\Mical^K1496

Species

D. melanogaster

Name

FlyBase ID

FBal0217516

Feature type

allele

Associated gene

Dmel\Mical

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Beuchle et al., 2007)

Progenitor genotype

Cytology

Description

Amino acid replacement: Q477term.

(Beuchle et al., 2007)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:10,019,954..10,019,954 [-]

Nucleotide change:

C10019954T

Amino acid change:

Reported amino acid change:

Q477term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Beuchle et al., 2007)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Beuchle et al., 2007)

abnormal neuroanatomy (with Df(3R)swp2^MICAL)

(Hung et al., 2013)

abnormal neuroanatomy (with Mical^I666)

(Beuchle et al., 2007)

abnormal neuroanatomy | larval stage (with Mical^I666)

(Beuchle et al., 2007)

abnormal neuroanatomy | third instar larval stage (with Df(3R)swp2^MICAL)

(Beuchle et al., 2007)

visible (with Df(3R)swp2^MICAL)

(Hung et al., 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

Mical^K1496/Df(3R)swp2^MICAL animals have axon guidance defects in ISNb, characterized by decreased axonal defasciculation/repulsion and a failure of axons to reach their correct targets.

(Hung et al., 2013)

Surviving Mical^K1496/Df(3R)swp2^MICAL adults almost always have defects in bristle morphology.

(Hung et al., 2010)

The synaptic territory (the muscle area covered by neuromuscular junctions) of Mical^I666/Mical^K1496 larvae contains clumps of densely packed boutons, many of which appear smaller.

The number of boutons in the cleft between muscles 6 and 7 is increased compared to controls in Mical^K1496/Df(3R)swp2^MICAL third instar larvae and the muscle 6+7 surface area is also consistently larger than wild type.

The sarcomeric pattern of the somatic muscles is disrupted in Mical^K1496 first instar larvae; the myosin filaments are organised in needle-like arrays and oriented along the longitudinal axis of muscle fibres, resembling the normal embryonic pre-sarcomeric state.

(Beuchle et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Df(3R)Exel6155/Mical^K1496 has flight muscle cell phenotype, non-suppressible by P{FlyFos-045847}

(Langer et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The phenotype of irregular flight muscle myofibrils that is seen in Mical^K1496/Df(3R)Exel6155 flies is not rescued if they are carrying the P{FlyFos-045847} construct (which contains D. pseudoobscura pseudoobscura fosmid sequence that includes the region orthologous to Mical).

(Langer et al., 2010)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

K1496

(Hung et al., 2010)

Mical^K1496

(Grintsevich et al., 2021, Yoon et al., 2017, Hung et al., 2013, Kirilly et al., 2009)

Mical^k1496

(Langer et al., 2010)

mical^K1496

(Beuchle et al., 2007)

milch^K1496

(Beuchle et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

Open Close