FB2026_02 , released June 18, 2026
Allele: Dmel\HimUAS.cLa
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General Information
Symbol
Dmel\HimUAS.cLa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Liotta
FlyBase ID
FBal0217519
Feature type
allele
Associated gene
Dmel\Him
Associated Insertion(s)
Carried in Construct
P{UAS-Him.L}
Also Known As
UAS-Him
Key Links
Transgenic product class
wild_type
(Liotta et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Liotta et al., 2007)
Mutagen
in vitro construct
(Liotta et al., 2007)
Progenitor genotype
Carried in construct
P{UAS-Him.L}
Cytology
Description

UAS regulatory sequences drive expression of Him.

(Liotta et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Him
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of HimScer\UAS.cLa under the control of Scer\GAL4twi.PB results in large gaps or holes in the musculature in embryos. Muscle development proceeds similarly to wild type in these embryos up to stage 13, but disrupted differentiation is seen at stage 15 and there is increased cell death at stage 16.

      Development of the musculature is inhibited in embryos expressing HimScer\UAS.cLa under the control of Scer\GAL4how-24B, and many of the residual muscles have abnormal morphology.

      (Liotta et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of Mef2Scer\UAS.cBa partially rescues the inhibition of muscle development seen in embryos expressing HimScer\UAS.cLa under the control of Scer\GAL4twi.PB and also partially rescues the lethality of these animals.

      The loss of muscles that is seen in embryos expressing HimScer\UAS.cLa under the control of Scer\GAL4twi.PB is suppressed if the embryos are also mutant for groE48/Df(3R)Espl22.

      (Liotta et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      HimScer\UAS.cLa
      HimUAS.cLa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Liotta
      Secondary FlyBase IDs
        References (3)