FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\ric8aP587
Open Close
General Information
Symbol
Dmel\ric8aP587
Species
D. melanogaster
Name
FlyBase ID
FBal0217737
Feature type
allele
Associated gene
Dmel\ric8a
Associated Insertion(s)
Carried in Construct
Also Known As
ric-8P587
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Wang et al., 2005)
Mutagen
Delta2-3 transposase
(Wang et al., 2005)
Progenitor genotype
P{EPgy2}CG17754EY05996
(Wang et al., 2005)
Cytology
Description

Imprecise excision of the P{EPgy2}CG17754EY05996 insertion, resulting in a deletion that removes the entire ric8a coding region (nucleotides -953 to +1853 relative to the ric8a transcription start site are removed).

(Wang et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      60% of mitotic domain 9 cells fail to re-orient their spindle by 90o in homozygous embryos derived from homozygous female germline clones. 16% of telophase neuroblasts divide into two similar-sized daughter cells in homozygous embryos derived from homozygous female germline clones.

      Stage 8 homozygous embryos derived from homozygous female germline clones show defects in gastrulation.

      The number of EL neurons per hemisegment is reduced compared to wild type in homozygous embryos derived from homozygous female germline clones.

      (Wang et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Neuroblasts of double mutant ric8aP587 ; Gβ13Ff261 embryos derived from double mutant ric8aP587 ; Gβ13Ff261 female germline clones show phenotypes similar to that seen in ric8aP587 homozygous embryos derived from ric8aP587 homozygous female germline clones.

      (Wang et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ric-8P587
      (Kanesaki et al., 2013, Wang et al., 2005)
      ric8aP587
      Name Synonyms
      Secondary FlyBase IDs
        References (2)