FB2026_02 , released June 18, 2026
Allele: Dmel\ric8a1
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General Information
Symbol
Dmel\ric8a1
Species
D. melanogaster
Name
FlyBase ID
FBal0217741
Feature type
allele
Associated gene
Dmel\ric8a
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Hampoelz et al., 2005)
Progenitor genotype
P{EPgy2}CG17754EY05996
(Hampoelz et al., 2005)
Cytology
Description

Imprecise excision of the P{EPgy2}CG17754EY05996 insertion, that results in a deletion that removes the N-terminal part of the ric8a coding region.

(Hampoelz et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      ric8a1 embryos lacking both maternal and zygotic ric8a function die as embryos with anterior and posterior holes in the cuticle (characteristic of defects in midgut invagination). These embryos also show defects in gastrulation that result in a twisting of the germband. 42% of the mitotic spindles in neuroblasts of ric8a1 embryos lacking both maternal and zygotic ric8a function are misoriented by more than 20o. Most of the mutant neuroblasts divide into more equal-size daughter cells than wild-type neuroblasts.

      The number of EL neurons per hemisegment is reduced compared to wild type in ric8a1 embryos lacking both maternal and zygotic ric8a function.

      (Hampoelz et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      ric8a1 is rescued by ric8a+tHa

      (Hampoelz et al., 2005)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ric8a1
      Name Synonyms
      Secondary FlyBase IDs
        References (1)