FB2026_02 , released June 18, 2026
Allele: Dmel\exAP50
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General Information
Symbol
Dmel\exAP50
Species
D. melanogaster
Name
FlyBase ID
FBal0217810
Feature type
allele
Associated gene
Dmel\ex
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    A rearrangement has resulted in a frameshift at codon 129, predicted to produce a protein truncated after the addition of a novel sequence of 34 amino acids following this codon.

    (Hamaratoglu et al., 2006)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        exAP50/exAP50 eyes (created by the EGUF method in otherwise heterozygous animals) contain significantly increased number of interomatidial cells (IOC) in the pupal retina compared to wild-type.

        The wing discs of exe1/exAP50 transheterozygotes are overgrown compared to controls.

        (Gaspar et al., 2015)

        exAP50 mutants exhibit delays in border cell migration. Polarisation of F-actin is abnormal in exAP50 mutant border cell clusters.

        (Lucas et al., 2013)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhanced by
        Statement
        Reference

        exAP50 has abnormal cell migration phenotype, enhanceable by kibraΔ32

        (Lucas et al., 2013)
        Enhancer of
        Statement
        Reference

        exAP50 is an enhancer of abnormal cell migration phenotype of kibraΔ32

        (Lucas et al., 2013)
        Phenotype Manifest In
        Enhanced by
        Statement
        Reference

        exAP50 has border follicle cell phenotype, enhanceable by kibraΔ32

        (Lucas et al., 2013)
        Suppressed by
        Enhancer of
        Statement
        Reference

        exAP50 is an enhancer of border follicle cell phenotype of kibraΔ32

        (Lucas et al., 2013)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The supernumerary inter-ommatidial cells in the pupal retina phenotype characteristic for exAP50/exAP50 eyes (created by the EGUF method in otherwise heterozygous animals) can be suppressed by combination with ZyxΔ41/ZyxΔ41.

        The overgrowth of the wing discs characteristic for exe1/exAP50 transheterozygotes can be suppressed by combination with ZyxΔ41/ZyxΔ41.

        (Gaspar et al., 2015)

        exAP50,kibraΔ32 double mutants exhibit a very severe delay in border cell migration, with clusters rarely even initiating migration.

        (Lucas et al., 2013)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        AP50Δ
        (Hamaratoglu et al., 2006)
        exAP50
        (Fletcher et al., 2018, Pascual et al., 2017, Gaspar et al., 2015, Lucas et al., 2013, Hamaratoglu et al., 2006)
        Name Synonyms
        Secondary FlyBase IDs
          References (5)