FlyBase Allele Report: Dmel\Asx[22P4]

General Information

Symbol

Dmel\Asx^22P4

Species

D. melanogaster

Name

FlyBase ID

FBal0218267

Feature type

allele

Associated gene

Dmel\Asx

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Scheuermann et al., 2010)

Mutagen

ethyl methanesulfonate

(de Ayala Alonso et al., 2007)

Progenitor genotype

Cytology

Description

Although Asx^22P4 homozygous embryos fail to express detectable amounts of Asx protein, a lesion in the Asx open reading frame has not been found.

(Scheuermann et al., 2010)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | somatic clone

(de Ayala Alonso et al., 2007)

Phenotype Manifest In

embryonic/first instar larval cuticle

(Gutiérrez et al., 2012)

embryonic abdominal segment 5

(Gutiérrez et al., 2012)

embryonic abdominal segment 6

(Gutiérrez et al., 2012)

embryonic abdominal segment 7

(Gutiérrez et al., 2012)

embryonic abdominal segment 8 | ectopic

(Gutiérrez et al., 2012)

wing | somatic clone

(de Ayala Alonso et al., 2007)

Detailed Description

Statement

Reference

Segments A5-A7 of the cuticle are partially transformed into copies of A8 in stage 16 homozygous embryos.

(Gutiérrez et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Asx^22P4 has embryonic/first instar larval cuticle phenotype, enhanceable by Sce^KO

(Gutiérrez et al., 2012)

Asx^22P4 has embryonic abdominal segment 8 | ectopic phenotype, enhanceable by Sce^KO

(Gutiérrez et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Sce^KO enhances the segmentation defects seen in Asx^22P4 embryos: segments T2-A7 in the cuticle are extensively, but not completely, transformed into copies of A8 in stage 16 double homozygous embryos.

(Gutiérrez et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

22P4

(de Ayala Alonso et al., 2007)

Asx⁰

(Bonnet et al., 2022)

Asx^22P4

(Luf et al., 2025, Bonnet et al., 2022, Dardalhon-Cuménal et al., 2018, Gutiérrez et al., 2012, Scheuermann et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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