FlyBase Allele Report: Dmel\GSd450[GSd450]

General Information

Symbol

Dmel\GSd450^GSd450

Species

D. melanogaster

Name

FlyBase ID

FBal0218607

Feature type

allele

Associated gene

GSd450

Associated Insertion(s)

P{GSV1}GSd450^GSd450

Carried in Construct

Also Known As

GSd450

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

P{GSV1}GSd450^GSd450

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{GSV1}

misexpression element

Regulatory region(s)

UASt

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | embryonic stage, with Scer\GAL4^scrt-11-6

(Minidorff et al., 2007)

abnormal neuroanatomy | first instar larval stage | somatic clone, with Scer\GAL4^Act5C.PP

(Ou et al., 2008)

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^109(2)80

(Ou et al., 2008)

lethal, with Scer\GAL4^scrt-11-6

(Minidorff et al., 2007, Minidorff et al., 2007)

Phenotype Manifest In

dendrite | first instar larval stage | somatic clone, with Scer\GAL4^Act5C.PP

(Ou et al., 2008)

dendrite | third instar larval stage, with Scer\GAL4^109(2)80

(Ou et al., 2008)

larval intersegmental nerve, with Scer\GAL4^scrt-11-6

(Minidorff et al., 2007)

larval longitudinal connective, with Scer\GAL4^scrt-11-6

(Minidorff et al., 2007)

larval multidendritic class III neuron | third instar larval stage, with Scer\GAL4^109(2)80

(Ou et al., 2008)

larval multidendritic class II neuron | third instar larval stage, with Scer\GAL4^109(2)80

(Ou et al., 2008)

larval multidendritic class I neuron | third instar larval stage, with Scer\GAL4^109(2)80

(Ou et al., 2008)

larval multidendritic class IV neuron | third instar larval stage, with Scer\GAL4^109(2)80

(Ou et al., 2008)

larval RP2 motor neuron | first instar larval stage | somatic clone, with Scer\GAL4^Act5C.PP

(Ou et al., 2008)

larval segmental nerve, with Scer\GAL4^scrt-11-6

(Minidorff et al., 2007)

larval ventral nerve cord, with Scer\GAL4^scrt-11-6

(Minidorff et al., 2007)

Detailed Description

Statement

Reference

Expression of GSd450^GSd450 under the control of Scer\GAL4^109(2)80 results in severe reduction of dendrite outgrowth and branching in the dendrites of dorsal cluster dendritic arborisation (da) neurons in third instar larvae (class I, II, III and IV da neurons are all affected), often accompanied by degeneration of the cell soma.

Isolated RP2 neuron clones expressing GSd450^GSd450 under the control of Scer\GAL4^Act5C.PP (clones generated using the Scer\FLP1^eve.RN2 line) show a reduction in dendrite branching at 25-31 hours after egg laying.

(Ou et al., 2008)

Fas2-positive axon bundles in the ventral nerve cord are fused and are seen misplaced within the connective in embryos expressing GSd450^GSd450 under the control of Scer\GAL4^scrt-11-6. The ventral nerve cord is thinned. In addition, in the periphery, the ISNb, ISNd, SNa and SNc motor neurons are missing or thinned.

(Minidorff et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

GSd450

(Ou et al., 2008)

GSd450^GSd450

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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