FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\AP-2μNN20
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General Information
Symbol
Dmel\AP-2μNN20
Species
D. melanogaster
Name
FlyBase ID
FBal0219041
Feature type
allele
Associated gene
Dmel\AP-2μ
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Windler and Bilder, 2010)
Mutagen
ethyl methanesulfonate
(Windler and Bilder, 2010, Menut et al., 2007)
Progenitor genotype
Cytology
Description

Amino acid replacement: M1I.

(Windler and Bilder, 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:22,462,605..22,462,605 [+]
Nucleotide change:

G22462605H

Amino acid change:

M1I | AP-2mu-PA; M1I | AP-2mu-PB; M1I | AP-2mu-PC

Reported amino acid change:

M1I

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Windler and Bilder, 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      AP-2μNN20 ddaC neuron clones within mosaic individuals present severe and highly penetrant dendrite pruning defects at 16h after puparium formation, as compared to controls.

      (Zong et al., 2018)

      Mutant eye discs (generated using the eyFLP-cell lethal system) show epithelial disorganisation accompanied by upregulated actin polymerisation and overgrowth.

      (Menut et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      AP-2μNN20
      (Zong et al., 2018, Windler and Bilder, 2010)
      AP-50NN20
      MENE (3R)-DNN20
      (Menut et al., 2007)
      MENE(3R)-DNN20
      Name Synonyms
      Secondary FlyBase IDs
        References (3)