FlyBase Allele Report: Dmel\p130CAS[UAS.Tag:MYC]

General Information

Symbol

Dmel\p130CAS^UAS.Tag:MYC

Species

D. melanogaster

Name

FlyBase ID

FBal0219081

Feature type

allele

Associated gene

Dmel\p130CAS

Associated Insertion(s)

Carried in Construct

P{UAS-p130CAS.Myc}

Key Links

Transgenic product class

wild_type

(Huang et al., 2007)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Huang et al., 2007)

Mutagen

in vitro construct

(Huang et al., 2007)

Progenitor genotype

Carried in construct

P{UAS-p130CAS.Myc}

Cytology

Description

UASt regulatory sequences drive expression of p130CAS which is tagged at the N-terminal end with Tag:MYC.

(Huang et al., 2007)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

p130CAS

Tagged with

Tag:MYC

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates tauopathy

modeled by Hsap\MAPT^4xA.UAS.2N4R

(Dourlen et al., 2017)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^elav.PLu

(Huang et al., 2007)

abnormal neuroanatomy, with Scer\GAL4^NP4466

(Huang et al., 2007)

Phenotype Manifest In

larval intersegmental nerve, with Scer\GAL4^elav.PLu

(Huang et al., 2007)

larval intersegmental nerve, with Scer\GAL4^NP4466

(Huang et al., 2007)

larval segmental nerve, with Scer\GAL4^elav.PLu

(Huang et al., 2007)

larval segmental nerve, with Scer\GAL4^NP4466

(Huang et al., 2007)

presumptive embryonic/larval central nervous system, with Scer\GAL4^elav.PLu

(Huang et al., 2007)

presumptive embryonic/larval central nervous system, with Scer\GAL4^NP4466

(Huang et al., 2007)

Detailed Description

Statement

Reference

Embryos expressing p130CAS^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^elav.PLu show axon guidance defects in the ISNb pathway, in the SNa pathway and in the central nervous system. The severity of the phenotype is dosage sensitive and the defects seen are characteristic of increased fasciculation in the ISNb pathway.

Embryos expressing p130CAS^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^{p130CAS-NP4466} show axon guidance defects in the ISNb pathway, in the SNa pathway and in the central nervous system. The defects seen are characteristic of increased fasciculation in the ISNb pathway.

(Huang et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^elav.PLu, p130CAS^UAS.Tag:MYC has abnormal neuroanatomy phenotype, suppressible | partially by mys¹/mys[+]

(Huang et al., 2007)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^elav.PLu, p130CAS^UAS.Tag:MYC has larval intersegmental nerve phenotype, suppressible | partially by mys¹/mys[+]

(Huang et al., 2007)

Scer\GAL4^elav.PLu, p130CAS^UAS.Tag:MYC has larval segmental nerve phenotype, suppressible | partially by mys¹/mys[+]

(Huang et al., 2007)

Scer\GAL4^elav.PLu, p130CAS^UAS.Tag:MYC has presumptive embryonic/larval central nervous system phenotype, suppressible | partially by mys¹/mys[+]

(Huang et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

The axon guidance defects seen in the ISNb pathway, SNa pathway and central nervous system of embryos expressing p130CAS^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^elav.PLu are significantly rescued by mys¹/+.

(Huang et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

p130CAS^UAS.Tag:MYC/Scer\GAL4^NP4466 partially rescues p130CAS^NP4466/Df(3L)ED201

(Huang et al., 2007)

p130CAS^UAS.Tag:MYC/Scer\GAL4^elav.PLu partially rescues Df(3L)Exel6083

(Huang et al., 2007)

Comments

Expression of p130CAS^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^{p130CAS-NP4466} partially rescues the axon guidance defects seen in the ISNb pathway, SNa pathway and central nervous system of p130CAS^NP4466/Df(3L)ED201 embryos.

Expression of p130CAS^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^elav.PLu partially rescues the axon guidance defects seen in the ISNb pathway, SNa pathway and central nervous system of Df(3L)Exel6083 homozygous embryos.

(Huang et al., 2007)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

^MycDCas

(Huang et al., 2007)

p130CAS^{Scer\UAS.T:Hsap\MYC}

p130CAS^UAS.Tag:MYC

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

Open Close