FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\dlD447
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General Information
Symbol
Dmel\dlD447
Species
D. melanogaster
Name
FlyBase ID
FBal0219239
Feature type
allele
Associated gene
Dmel\dl
Associated Insertion(s)
P{GSV1}GSd447
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Minidorff et al., 2007)
Progenitor genotype
P{GSV1}GSd447
(Minidorff et al., 2007)
Associated Insertion(s)
P{GSV1}GSd447
Cytology
Description

Amino acid replacement: Q453term.

(Minidorff et al., 2007)

The P{GSV1}dlGSd447 insertion is still present on the mutant chromosome, in addition to the nonsense mutation in the dl-A isoform.

(Minidorff et al., 2007)
Allele components
Component
Use(s)
Inserted element
P{GSV1}
Regulatory region(s)
UASt
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:17,437,820..17,437,820 [-]
Nucleotide change:

C17437820T

Amino acid change:

Q453term | dl-PA; Q453term | dl-PB; Q453term | dl-PD; Q453term | dl-PE

Reported amino acid change:

Q453term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Minidorff et al., 2007)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Animals carrying dlD447 and Scer\GAL4GMR.PF have almost normal photoreceptor axon targeting in the retina.

      Embryos derived from dlD447/Df(2L)H20 females are strongly dorsalised.

      dlD447/Df(2L)H20 and dlD447/Df(2L)TW119 larvae do not have photoreceptor R2-R5 axon targeting defects in the visual system.

      (Minidorff et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      dl1

      (Minidorff et al., 2007)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      GSd447*D
      (Minidorff et al., 2007)
      dlD447
      (Minidorff et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)