FlyBase Allele Report: Dmel\Atg7[d4]

General Information

Symbol

Dmel\Atg7^d4

Species

D. melanogaster

Name

FlyBase ID

FBal0219650

Feature type

allele

Associated gene

Dmel\Atg7

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Juhász et al., 2007)

Progenitor genotype

Atg7^d06996

(Juhász et al., 2007)

Cytology

Description

Imprecise excision of the insertion in Atg7^d06996, resulting in a deletion that removes the last 3 exons of Atg7.

(Juhász et al., 2007)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage

(Kiral et al., 2020)

abnormal neuroanatomy | P-stage

(Kiral et al., 2020)

abnormal neurophysiology | adult stage | somatic clone - tissue specific

(Kiral et al., 2020)

abnormal visual behavior | adult stage

(Kiral et al., 2020)

decreased cell death | somatic clone

(Nezis et al., 2009)

viable

(Juhász et al., 2007)

Phenotype Manifest In

Detailed Description

Statement

Reference

Cell death in the germarium of Atg7^d4 germline clones is reduced to 13.8% (compared to 26% of the control) and to 4.8% for mid-stage egg chambers (compared to 9.7% of the control).

(Nezis et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Atg7^d4 has abnormal neuroanatomy | adult stage phenotype, non-suppressible by Scer\GAL4^GMR.PU/Atg6^{UAS.ORF.GW.Tag:HA}

(Kiral et al., 2020)

Atg7^d4 has abnormal neuroanatomy | P-stage phenotype, non-suppressible by Scer\GAL4^GMR.PU/Atg6^{UAS.ORF.GW.Tag:HA}

(Kiral et al., 2020)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Atg7^d4 has synapse | increased number | adult stage phenotype, non-suppressible by Scer\GAL4^GMR.PU/Atg6^{UAS.ORF.GW.Tag:HA}

(Kiral et al., 2020)

Atg7^d4 has filopodium | increased number | P-stage phenotype, non-suppressible by Scer\GAL4^GMR.PU/Atg6^{UAS.ORF.GW.Tag:HA}

(Kiral et al., 2020)

Atg7^d4 has eye photoreceptor cell | adult stage phenotype, non-suppressible by Scer\GAL4^GMR.PU/Atg6^{UAS.ORF.GW.Tag:HA}

(Kiral et al., 2020)

Atg7^d4 has axon | P-stage phenotype, non-suppressible by Scer\GAL4^GMR.PU/Atg6^{UAS.ORF.GW.Tag:HA}

(Kiral et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

95244

w^*; Atg7^d4/CyO, P{ActGFP}JMR1

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Atg7^d4

(Thomas et al., 2018, Tian et al., 2015, Chang et al., 2013, Vincow et al., 2013, Barth et al., 2011, Nezis et al., 2009)

Atg7^Δ4

(Barth et al., 2011)

atg7^d4

(Kiral et al., 2020, Zhao et al., 2018, Mukherjee et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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