FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\TwdlL93
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General Information
Symbol
Dmel\TwdlL93
Species
D. melanogaster
Name
FlyBase ID
FBal0219681
Feature type
allele
Associated gene
Dmel\TwdlL
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Cook, 2008.12.1)
Progenitor genotype
Cytology
Description

Tyr to Cys missense mutation in a conserved block of the DUF243 domain in TwdlL.

(Zuber et al., 2020)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:26,624,979..26,624,979 [-]
Nucleotide change:

A26624979G

Amino acid change:

Y187C | TwdlL-PA; Y181C | TwdlL-PB

Reported amino acid change:

Y181C

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Zuber et al., 2020)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      TwdlL93 homozygous larvae start to exhibit abnormal body size (shorter and wider compared to controls) at the first instar larval stage. TwdlL93 homozygous larvae also exhibit electron-dense aggregates immersed within the procuticle; epidermal cells which are shorter along the anterior posterior axis and longer along the dorsoventral axis of the animal; and the inner cuticular surface of larvae that form convexities but are comparably flat with random orientation.

      (Zuber et al., 2020)

      Tb93 has a dominant phenotype similar to Tb1.

      (Cook, 2008.12.1)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      TwdlL93 is rescued by TwdlLKK113269/Scer\GAL4e22c

      (Zuber et al., 2020)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Tb93 maps to the same chromosomal region as Tb, so allelism is assumed.

      (Cook, 2008.12.1)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Tb93
      (Zuber et al., 2020, Cook, 2008.12.1)
      TwdlL93
      (Zuber et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)