FlyBase Allele Report: Dmel\Chd1[4]

General Information

Symbol

Dmel\Chd1⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0220143

Feature type

allele

Associated gene

Dmel\Chd1

Associated Insertion(s)

P{?EP}Chd1⁴

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(McDaniel et al., 2008)

Progenitor genotype

P{EP}Chd1^G2213

(McDaniel et al., 2008)

Associated Insertion(s)

P{?EP}Chd1⁴

Cytology

Description

Imprecise excision of the P{EP}G2213 insertion, resulting in a deletion that removes nucleotides -1 to +1994 of the Chd1 gene, plus an insertion of the additional sequence CATGATGAAATAACATATAGTTAGATATGAAATAA (much of this additional sequence is derived from the P-element sequences of the original insertion).

(McDaniel et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate

(McDaniel et al., 2008)

abnormal developmental rate (with Chd1⁵)

(McDaniel et al., 2008)

abnormal developmental rate (with Df(2L)Exel7014)

(McDaniel et al., 2008)

female semi-sterile (with Chd1⁵)

(McDaniel et al., 2008)

female sterile (with Df(2L)Exel7014)

(McDaniel et al., 2008)

male sterile (with Chd1⁵)

(McDaniel et al., 2008)

viable

(McDaniel et al., 2008)

viable (with Chd1⁵)

(McDaniel et al., 2008)

viable (with Df(2L)Exel7014)

(McDaniel et al., 2008)

visible (with Chd1⁵)

(McDaniel et al., 2008)

visible (with Df(2L)Exel7014)

(McDaniel et al., 2008)

Phenotype Manifest In

wing (with Chd1⁵)

(McDaniel et al., 2008)

wing (with Df(2L)Exel7014)

(McDaniel et al., 2008)

Detailed Description

Statement

Reference

Homozygous, Chd1⁴/Chd1⁵ and Chd1⁴/Df(2L)Exel7014 animals show a 1- to 2- day developmental delay.

Chd1⁴/Chd1⁵ and Chd1⁴/Df(2L)Exel7014 adults show wing notching.

Chd1⁴/Chd1⁵ males show normal mating behaviours and have no obvious defects in testis morphology, but no offspring are produced when they are mated to Oregon-R virgin females.

Chd1⁴/Chd1⁵ females produce few offspring compared to control females.

Chd1⁴/Df(2L)Exel7014 females produce almost no progeny. While eggs are occasionally formed in these females, oogenesis often fails at stage 8.

(McDaniel et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Chd1⁴

(Berson et al., 2017)

chd1⁴

(Kim et al., 2015, Bugga et al., 2013, McDaniel et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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