FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ChcDN.UAS
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General Information
Symbol
Dmel\ChcDN.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0220358
Feature type
allele
Associated gene
Dmel\Chc
Associated Insertion(s)
Carried in Construct
P{UAS-Chc.DN}
Also Known As
ChcDN, UAS-ChcDN
Key Links
Transgenic product class
dominant_negative_variant
(Parks and Muskavitch, 2009.3.2)
inframe_deletion
(Parks and Muskavitch, 2009.3.2)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Parks and Muskavitch, 2009.3.2)
inframe_deletion
(Parks and Muskavitch, 2009.3.2)
Mutagen
in vitro construct
(Parks and Muskavitch, 2009.3.2)
Progenitor genotype
Carried in construct
P{UAS-Chc.DN}
Cytology
Description

UAS regulatory sequences drive expression of a dominant negative form of Chc (which consists of the carboxy-terminal amino acids 1075 to 1678).

(Parks and Muskavitch, 2009.3.2)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Chc
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In pupae expression of ChcDN.UAS under the control of Scer\GAL4GMR.long leads to smaller rhabdomeres while it does not alter the rhabdomere and stalk segregation when compared to controls.

      (Ogi et al., 2019)

      Third larval instar adipocytes expressing ChcDN.Scer\UAS under the control of Scer\GAL4SPARC-MI00329-GAL4 show a significant increase in plasma membrane depth compared to control cells.

      (Zang et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      ChcDN.Scer\UAS
      ChcDN.UAS
      ChcDN
      (Zang et al., 2015)
      chcDN
      (Peng et al., 2021)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)