FB2026_02 , released June 18, 2026
Allele: Dmel\HSPC300EP506
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General Information
Symbol
Dmel\HSPC300EP506
Species
D. melanogaster
Name
FlyBase ID
FBal0220484
Feature type
allele
Associated gene
Dmel\HSPC300
Associated Insertion(s)
P{EP}EP506
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - genetic evidence

    (Qurashi et al., 2007)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{EP}EP506
    Cytology
    Description

    Insertion 75bp upstream of the start codon, in the correct orientation to drive HSPC300 expression from the Scer\UAS sites in the insertion.

    (Qurashi et al., 2007)
    Allele components
    Component
    Use(s)
    Inserted element
    P{EP}
    Regulatory region(s)
    UAS
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Homozygotes are 100% viable. HSPC300EP506/HSPC300Δ54.3 animals show 30% viability.

        Zygotic null, maternal hypomorph embryos (derived from HSPC300EP506/HSPC300Δ54.3 females mated to HSPC300Δ54.3/+ males) sometimes show abnormal crossing of the midline by axons (10% of embryos), and in the most severe cases, axons ectopically cross the midline several times. Commissures and longitudinal connectives are not properly formed.

        (Qurashi et al., 2007)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        HSPC300EP506
        (Zhu and Bhat, 2011, Qurashi et al., 2007)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)