FB2026_03 , released September 17, 2026
Allele: Dmel\SdhCI71E.UAS
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General Information
Symbol
Dmel\SdhCI71E.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0220829
Feature type
allele
Associated gene
Dmel\SdhC
Associated Insertion(s)
Carried in Construct
P{UAS-SdhC.I71E}
Key Links
Transgenic product class
dominant_negative_variant
(Tsuda et al., 2007)
missense_variant
(Tsuda et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Tsuda et al., 2007)
missense_variant
(Tsuda et al., 2007)
Mutagen
in vitro construct
(Tsuda et al., 2007)
Progenitor genotype
Carried in construct
P{UAS-SdhC.I71E}
Cytology
Description

UASt regulatory sequences drive expression of a dominant negative form of SdhC (carries a I71E amino acid replacement).

(Tsuda et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
SdhC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of SdhCI71E.Scer\UAS under the control of Scer\GAL4elav.Switch.PO in the presence of RU-486 results in a significant reduction in adult lifespan (mean lifespan is reduced by 22% compared to controls).

      (Tsuda et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      SdhCI71E.Scer\UAS
      SdhCI71E.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)