FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\eggRNAi.UAS.cBa
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General Information
Symbol
Dmel\eggRNAi.UAS.cBa
Species
D. melanogaster
Name
FlyBase ID
FBal0221222
Feature type
allele
Associated gene
Dmel\egg
Associated Insertion(s)
Carried in Construct
P{UAS-dSETDB1.RNAi.B}
Key Links
Transgenic product class
RNAi_reagent
(Brower-Toland et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Brower-Toland et al., 2009)
Mutagen
in vitro construct
(Brower-Toland et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-dSETDB1.RNAi.B}
Cytology
Description

UAS regulatory sequences drive expression of a hairpin repeat of sequences corresponding to part of egg.

(Brower-Toland et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
egg
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of eggdsRNA.hp.Scer\UAS under the control of Scer\GAL4Act5C results in a number of defects; larvae are more sluggish in their feeding and wandering behaviour than normal, animals often fail to eclose from the pupal case, and newly eclosed adults often fail to complete wing expansion. Surviving adult males and females have shorter lifespans than normal, often dying within 2 days of eclosion. Males show a significantly lower survival to adulthood than females.

      Expression of eggdsRNA.hp.Scer\UAS under the control of Scer\GAL4nos.PG decreased egg production.

      Expression of eggdsRNA.hp.Scer\UAS under the control of Scer\GAL4da.G32 results in suppression of w variegation of the "118E-28" line (which contains the P{hsp26-pt-T}118E-28a and P{hsp26-pt-T}118E-28b insertions).

      Expression of eggdsRNA.hp.Scer\UAS under the control of Scer\GAL4da.G32 results in suppression of w variegation of the P{hsp26-pt-T}39C-12, P{hsp26-pt-T}39C-2, P{hsp26-pt-T}118E-10 and P{hsp26-pt-T}118E-25-5 insertions.

      Expression of eggdsRNA.hp.Scer\UAS under the control of Scer\GAL4nos.PG has no effect on the degree of w variegation of the P{hsp26-pt-T}118E-10 and P{hsp26-pt-T}39C-12 insertions.

      Expression of eggdsRNA.hp.Scer\UAS under the control of Scer\GAL4ey.200.Exel results in suppression of w variegation of the P{hsp26-pt-T}118E-10 and P{hsp26-pt-T}39C-12 insertions.

      (Brower-Toland et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Suppressed by
      Statement
      Reference

      Scer\GAL4Act5C.PU, eggRNAi.UAS.cBa has lethal phenotype, suppressible by Scer\GAL4Act5C.PU

      (Brower-Toland et al., 2009)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The degree of lethality of females expressing eggdsRNA.hp.Scer\UAS under the control of Scer\GAL4Act5C is decreased if they are also carrying Su(var)3-96.

      (Brower-Toland et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      dSETDB1KD
      (Brower-Toland et al., 2009)
      dSETDB1hp2101B
      (Brower-Toland et al., 2009)
      eggRNAi.UAS.cBa
      eggdsRNA.hp.Scer\UAS
      eggdsRNA.hp.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)