FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\LAMP1UAS.EGFP
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General Information
Symbol
Hsap\LAMP1UAS.EGFP
Species
H. sapiens
Name
FlyBase ID
FBal0221465
Feature type
allele
Associated gene
Hsap\LAMP1
Associated Insertion(s)
Carried in Construct
P{UAS-GFP-LAMP}
Also Known As
UAS-GFP-Lamp1, UAS-Lamp1-GFP, LAMP1-GFP, GFP-LAMP1, LAMP-GFP, UAS-GFP-LAMP, GFP-LAMP, UAS GFP-Lamp1, UAS-LAMP-GFP, UAS-GFP:Lamp1
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Pulipparacharuvil et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-GFP-LAMP}
Cytology
Description

UASt regulatory sequences drive expression of a cleavable preprolactin signal sequence, followed by EGFP and then the transmembrane domain and cytoplasmic tail of Hsap\LAMP1 (the cytoplasmic tail is sufficient to direct the protein produced to late endosomes and lysosomes).

(Pulipparacharuvil et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\LAMP1
Tagged with
EGFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      late endosome
      (Vaccari et al., 2010)
      lysosome
      (Vaccari et al., 2010)
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      Hsap\LAMP1UAS.EGFP/Scer\GAL4hh-Gal4 is a non-enhancer of phenotype of l(2)gd1d7

      (Schneider et al., 2013)
      NOT Suppressor of
      Statement
      Reference

      Hsap\LAMP1UAS.EGFP/Scer\GAL4hh-Gal4 is a non-suppressor of phenotype of l(2)gd1d7

      (Schneider et al., 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Scer\GAL4hh-Gal4-mediated expression of Hsap\LAMP1Scer\UAS.T:Avic\GFP-EGFP has no effect on the ectopic N activation phenotype (ectopic expression of wg) in the posterior of l(2)gd1d7 wing discs.

      (Schneider et al., 2013)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\LAMP1Scer\UAS.T:Avic\GFP-EGFP
      Hsap\LAMP1UAS.EGFP
      Name Synonyms
      Secondary FlyBase IDs
        References (74)