FB2026_02 , released June 18, 2026
Allele: Hsap\MANFUAS.9C
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General Information
Symbol
Hsap\MANFUAS.9C
Species
H. sapiens
Name
Saccharomyces cerevisiae UAS construct a of Palgi
FlyBase ID
FBal0221498
Feature type
allele
Associated gene
Hsap\MANF
Associated Insertion(s)
Carried in Construct
P{UAS-HsMANF.9C}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Palgi et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-HsMANF.9C}
Cytology
Description

UASt regulatory sequences drive expression of Hsap\MANF. The signal sequence of Hsap\MANF has been replaced with honeybee mellitin signal sequence. 9 extra C-terminal amino acid residues have been introduced during cloning process.

(Palgi et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\MANF
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Hsap\MANFScer\UAS.cPa under the control of one of Scer\GAL4da.G32 or Scer\GAL4tub significantly rescues the larval lethality of ManfΔ96 animals (assayed by survival into the pupal stage).

      (Palgi et al., 2009)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Hsap\MANFScer\UAS.9C
      Hsap\MANFScer\UAS.cPa
      Hsap\MANFUAS.9C
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Palgi
      Secondary FlyBase IDs
        References (1)