FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ADD1NP0793
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General Information
Symbol
Dmel\ADD1NP0793
Species
D. melanogaster
Name
FlyBase ID
FBal0222152
Feature type
allele
Associated gene
Dmel\ADD1
Associated Insertion(s)
P{GawB}ADD1NP0793
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - molecular evidence

    (López-Falcón et al., 2014)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GawB}ADD1NP0793
    Cytology
    Description

    Insertion in the 5'UTR of ADD1 which results in reduced levels of ADD1 mRNA compared to wild type. Insertion is at +81bp relative to the transcription start site and at -225bp relative to the translation initiation codon.

    (López-Falcón et al., 2014)
    Allele components
    Component
    Use(s)
    Inserted element
    P{GawB}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        ADD1NP0793/ADD1NP1240 flies have reduced viability and no melanotic masses (ADD1NP1240/+ or ADD1NP0793/+ flies are viable and have no melanotic masses).

        ADD1NP0793 suppresses variegation of the Ecol\lacZ reporter carried on In(3L)BL1.

        (López-Falcón et al., 2014)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        ADD1NP0793/+;XNP1/+, ADD1NP0793/+;XNP2/+, or ADD1NP0793/+;XNP3/+ flies are viable and a small percentage of adults (3%) have melanotic masses.

        ADD1NP0793/+;XNP2/XNP3 flies show partial lethality (more flies survive than in XNP2/XNP3 alone) and have melanotic masses (9%).

        ADD1NP0793 or or XNP3 suppresses variegation of the Ecol\lacZ reporter carried on In(3L)BL1; this suppression is further enhanced in ADD1NP0793/+;XNP3/+ flies.

        (López-Falcón et al., 2014)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        ADD1NP0793
        CG8290NP0793
        dadd1NP0793
        (López-Falcón et al., 2014)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)