FlyBase Allele Report: Dmel\park[f01950]

General Information

Symbol

Dmel\park^f01950

Species

D. melanogaster

Name

FlyBase ID

FBal0222684

Feature type

allele

Associated gene

Dmel\park

Associated Insertion(s)

PBac{WH}park^f01950

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

PBac{WH}park^f01950

Cytology

Description

Allele components

Component

Use(s)

Inserted element

PBac{WH}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:21,196,542..21,196,542 [+]

(FlyBase Curators, 2008-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of opportunistic bacterial infectious disease

CEA

(Manzanillo et al., 2013)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response | adult stage

(Manzanillo et al., 2013)

abnormal size | third instar larval stage (with park^Δ21)

(Tan et al., 2018)

short lived (with park^Δ21)

(Tan et al., 2018)

viable (with park^Δ21)

(Tan et al., 2018)

Phenotype Manifest In

embryonic/larval hypodermal muscle cell | third instar larval stage (with park^Δ21)

(Tan et al., 2018)

nuclear envelope | third instar larval stage (with park^Δ21)

(Tan et al., 2018)

nucleus | third instar larval stage (with park^Δ21)

(Tan et al., 2018)

Detailed Description

Statement

Reference

Body wall muscles in park^Δ21/park^f01950 transheterozygous third instar larvae frequently show nuclei clustering together or in contact with each other, instead of the typically even spaced in controls; these nuclei also exhibit a smaller size and an irregular shape (uneven nuclear envelope). Nuclei clustering is not observed in the park^f01950 heterozygous background.

(Tan et al., 2018)

Adult park^f01950 mutant flies are highly susceptible to Listeria monocytogenes, Salmonella enterica and Mycobacterium marinum infections and display significantly lower survival rate upon infection as well as higher post-infection pathogen load compared to wild-type.

(Manzanillo et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

park^f01950/park^Δ21 has short lived phenotype, suppressible by Hsap\ARIH1^UAS.cFa/Scer\GAL4^da.G32

(Tan et al., 2018)

Enhancer of

Statement

Reference

park^f01950/park^f01950 is an enhancer of lethal - all die before end of pupal stage | recessive phenotype of ari-1^B

(Tan et al., 2018)

Other

Statement

Reference

ari-1^A, park^f01950/park[+] has abnormal size | third instar larval stage phenotype

(Tan et al., 2018)

ari-1^B, park^f01950/park[+] has abnormal size | third instar larval stage phenotype

(Tan et al., 2018)

Phenotype Manifest In

Other

Statement

Reference

ari-1^A, park^f01950/park[+] has nucleus | third instar larval stage phenotype

(Tan et al., 2018)

ari-1^A, park^f01950/park[+] has embryonic/larval hypodermal muscle cell | third instar larval stage phenotype

(Tan et al., 2018)

ari-1^B, park^f01950/park[+] has nucleus | third instar larval stage phenotype

(Tan et al., 2018)

ari-1^B, park^f01950/park[+] has embryonic/larval hypodermal muscle cell | third instar larval stage phenotype

(Tan et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

Body wall muscles in ari-1^B/+,park^f01950/+, ari-1^B/Y,park^f01950/+, ari-1^A/+,park^f01950/+ or ari-1^A/Y,park^f01950/+ third instar larvae frequently show nuclei clustering together or in contact with each other, instead of the typically even spaced in controls; these nuclei also exhibit a smaller size and an irregular shape (uneven nuclear envelope).

(Tan et al., 2018)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

park^F01590

(Tan et al., 2018)

park^f01950

(Tan et al., 2018, Manzanillo et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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