FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Fmr15-HA-1014
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General Information
Symbol
Dmel\Fmr15-HA-1014
Species
D. melanogaster
Name
FlyBase ID
FBal0226530
Feature type
allele
Associated gene
Dmel\Fmr1
Associated Insertion(s)
P{RS5}Fmr15-HA-1014
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{RS5}Fmr15-HA-1014
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Also carries
    FRT
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 1 )
        Disease
        Evidence
        References
        model of  autism spectrum disorder
        CEA
        (Dong et al., 2016)
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        model of  autism spectrum disorder
        is ameliorated by Rac1V12.UAS
        (Dong et al., 2016)
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Fmr15-HA-1014/Fmr15-HA-1014 mutants do not exhibit defective learning in an aversive conditioning assay, but do exhibit severe defects in a reversal-learning paradigm, with a third-odor preference assay showing an inability to forget the first aversive odor association after training with a second aversive odor; these flies also show a significantly slower decay in memory performance with increased time after training, and interference-induced forgetting is blocked in these mutants, as compared to wild type.

        (Dong et al., 2016)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressed by
        NOT suppressed by
        Statement
        Reference

        Fmr15-HA-1014 has abnormal learning | adult stage phenotype, non-suppressible by Scer\GAL4elav.Switch.PO/Rac1N17.UAS

        (Dong et al., 2016)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Expression of Rac1V12.Scer\UAS (but not Rac1N17.Scer\UAS) under the control of Scer\GAL4elav.Switch.PO (and feeding with RU486 to induce expression via the GeneSwitch system) significantly suppresses the reversal-learning defect observed in Fmr15-HA-1014/Fmr15-HA-1014 mutants.

        (Dong et al., 2016)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        Fmr15-HA-1014
        (Dong et al., 2016)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)