FB2026_03 , released September 17, 2026
Allele: Dmel\fab121
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General Information
Symbol
Dmel\fab121
Species
D. melanogaster
Name
FlyBase ID
FBal0230154
Feature type
allele
Associated gene
Dmel\fab1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Rusten et al., 2006)
Mutagen
ethyl methanesulfonate
(Rusten et al., 2006)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q1521term.

(Rusten et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      fab121 mutant photoreceptor terminals show increased accumulation of autophagic vacuoles compared to controls.

      (Tian et al., 2015)

      Third larval instar eye-antennal discs have normal morphology.

      (Morelli et al., 2014)

      fab121/fab131 larvae show accumulation of amphisomes in eye disc cells.

      (Rusten et al., 2007)

      Mosaic flies in which the head is primarily composed of homozygous cells are viable and have an enlarged head and eyes.

      (Rusten et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      fab131

      (Rusten et al., 2006)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      fab-12-1
      (Vaccari et al., 2008)
      fab121
      (Tian et al., 2015, Morelli et al., 2014, Rusten et al., 2007, Rusten et al., 2006)
      l(2)SJB21
      (Rusten et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)