FB2026_02 , released June 18, 2026
Allele: Dmel\LKRSDHRNAi.UAS
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General Information
Symbol
Dmel\LKRSDHRNAi.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0230263
Feature type
allele
Associated gene
Dmel\LKRSDH
Associated Insertion(s)
Carried in Construct
P{UAS-KTR.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Cakouros et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Cakouros et al., 2008)
Mutagen
in vitro construct
(Cakouros et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-KTR.RNAi}
Cytology
Description

UAS regulatory sequences drive expression of inverted repeats corresponding to LKRSDH coding regions.

(Cakouros et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
LKRSDH
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Down-regulation of LKR through expression of LKRIR.Scer\UAS during wing development using Scer\GAL4e22c results in significantly smaller wings when compared with control flies.

      Down-regulation of LKR through expression of LKRIR.Scer\UAS in the salivary glands under the control of Scer\GAL4Sgs3.PD fails to generate any discernible alterations in tissue histolysis or metamorphosis.

      (Cakouros et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      LKRSDHRNAi.UAS has wing phenotype, suppressible by Scer\GAL4e22c/EcRA-ΔC655.F645A.UAS

      (Cakouros et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Knock-down of LKR through LKRIR.Scer\UAS partially restores the pigmentation defect found in EcRA-ΔC655.F645A.Scer\UAS (Scer\GAL4GMR.PF) mutants and display a striking decrease of scarring compared to expression of EcRA-ΔC655.F645A.Scer\UAS (Scer\GAL4GMR.PF) alone.

      Expression of EcRA-ΔC655.F645A.Scer\UAS restores the small wing phenotype caused by LKRIR.Scer\UAS.

      (Cakouros et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      LKRIR.Scer\UAS
      LKRdsRNA.Scer\UAS
      LKRSDHRNAi.UAS
      LKRSDHdsRNA.Scer\UAS
      LKRSDHdsRNA.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)