FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\groMB36
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General Information
Symbol
Dmel\groMB36
Species
D. melanogaster
Name
FlyBase ID
FBal0230454
Feature type
allele
Associated gene
Dmel\gro
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Jennings et al., 2008)
Progenitor genotype
Cytology
Description

Mutation results in an ectopic splice acceptor site in an intron, resulting in a frameshift from amino acid residue 13.

(Jennings et al., 2008)

Nucleotide substitution: G138A.

(Jennings et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:26,043,481..26,043,481 [+]
Nucleotide change:

G26043481A

Reported nucleotide change:

G138A

Comment:

Nucleotide substitution: GG to AG creating a new splice acceptor, frameshift at thirteenth codon. Same nucleotide substitution as gro[MB15]. Position of mutation on reference sequence inferred by FlyBase curator.

(Jennings et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos derived from homozygous females show severe cuticle loss due to ectopic neurogenesis at the expense of epidermal development.

      (Jennings et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      groMB36/gro[+] is a suppressor of eye phenotype of hryUAS.cIa

      (Jennings et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      groMB36 is rescued by gro+t10

      (Turki-Judeh and Courey, 2012)
      Partially rescued by

      groMB36 is partially rescued by groΔSP

      (Turki-Judeh and Courey, 2012)
      Not rescued by

      groMB36 is not rescued by groΔGP

      (Turki-Judeh and Courey, 2012)

      groMB36 is not rescued by groΔCcN

      (Turki-Judeh and Courey, 2012)
      Comments

      gro+t10 completely rescues the lethality of groMB36 homozygotes.

      groΔGP and groΔCcN each fail to rescue the lethality of groMB36 homozygotes.

      groΔSP partially rescues the lethality of groMB36 homozygotes.

      (Turki-Judeh and Courey, 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: A modifier of the eye phenotype caused by expression of hScer\UAS.cIa under the control of Scer\GAL4GMR.PF.

      (Jennings et al., 2008)
      Comments
      Comments

      groMB15 and groMB36 contain the same lesion.

      (Jennings et al., 2008)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      References (6)