FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\groMB18
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General Information
Symbol
Dmel\groMB18
Species
D. melanogaster
Name
FlyBase ID
FBal0230455
Feature type
allele
Associated gene
Dmel\gro
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Jennings et al., 2008)
Progenitor genotype
Cytology
Description

Mutation in a splice junction, resulting in a frameshift from amino acid residue 45, as intronic sequences are transcribed.

(Jennings et al., 2008)

Nucleotide substitution: G266A.

(Jennings et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:26,043,610..26,043,610 [+]
Nucleotide change:

G26043610A

Reported nucleotide change:

G266A

Comment:

Nucleotide substitution: GC changed to AT in the splice donor, leading to retention of intron. Translation continues past the peptide sequence EFNFLQAQYH into the retained intron. Position of mutation on reference sequence inferred by FlyBase curator.

(Jennings et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      groMB18/gro[+] is a suppressor of eye phenotype of hryUAS.cIa

      (Jennings et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: A modifier of the eye phenotype caused by expression of hScer\UAS.cIa under the control of Scer\GAL4GMR.PF.

      (Jennings et al., 2008)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      groMB18
      (Jennings et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)