FB2026_02 , released June 18, 2026
Allele: Dmel\groMB5
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General Information
Symbol
Dmel\groMB5
Species
D. melanogaster
Name
FlyBase ID
FBal0230457
Feature type
allele
Associated gene
Dmel\gro
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Jennings et al., 2008)
Progenitor genotype
Cytology
Description

Complex deletion and change that leads to an 8-amino acid deletion/1-amino acid substitution lacking the first 4 amino acid residues of the AH1 helix (amino acids 19-27 are deleted and the 19th residue is changed from Pro to Ser).

(Jennings et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:26,043,534..26,043,557 [+]
Reported nucleotide change:

delta191-214

Reported amino acid change:

Delta19-27

Comment:

In frame deletion of residues 19-27 that, together with the adjacent C-to-T nucleotide change just upstream, results in replacement of PIKFTIADT peptide with a single Serine codon. One of three nucleotide changes observed in gro[MB5] mutant. Position of mutation on reference sequence inferred by FlyBase curator.

(Jennings et al., 2008)
point_mutation
3R:26,043,532..26,043,532 [+]
Nucleotide change:

T26043532C

Reported nucleotide change:

T189C

Amino acid change:

G18G | gro-PA; G18G | gro-PB; G18G | gro-PC; G18G | gro-PD; G18G | gro-PE; G18G | gro-PF; G18G | gro-PG; G18G | gro-PH; G18G | gro-PI; G18G | gro-PJ

Comment:

One of three nucleotide changes observed in gro[MB5] mutant. Position of mutation on reference sequence inferred by FlyBase curator.

(Jennings et al., 2008)
point_mutation
3R:26,043,533..26,043,533 [+]
Nucleotide change:

C26043533T

Reported nucleotide change:

C190T

Amino acid change:

P19S | gro-PA; P19S | gro-PB; P19S | gro-PC; P19S | gro-PD; P19S | gro-PE; P19S | gro-PF; P19S | gro-PG; P19S | gro-PH; P19S | gro-PI; P19S | gro-PJ

Reported amino acid change:

P19S

Comment:

One of three nucleotide changes observed in gro[MB5] mutant. Position of mutation on reference sequence inferred by FlyBase curator.

(Jennings et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant embryos show loss of alternate ventral denticle belts. This segmentation phenotype is weak, with usually only 2-3 even-numbered denticle belts being missing (0% are wild type, 5% lack one belt, 27% lack two belts, 52% lack three belts and 16% lack more than three belts).

      (Jennings et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      groMB5/gro[+] is a suppressor of visible phenotype of Chie5.5

      (van Tienen et al., 2017)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      groMB5/gro[+] is a suppressor of wing phenotype of Chie5.5

      (van Tienen et al., 2017)

      groMB5/gro[+] is a suppressor of eye phenotype of hryUAS.cIa

      (Jennings et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The wing notch phenotype seen in Chie5.5/+ mutants is partially suppressed by the presence of groMB5/+.

      (van Tienen et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: A modifier of the eye phenotype caused by expression of hScer\UAS.cIa under the control of Scer\GAL4GMR.PF.

      (Jennings et al., 2008)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      groMB5
      (van Tienen et al., 2017, Jennings et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)