FB2026_02 , released June 18, 2026
Allele: Dmel\groMB12
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General Information
Symbol
Dmel\groMB12
Species
D. melanogaster
Name
FlyBase ID
FBal0230458
Feature type
allele
Associated gene
Dmel\gro
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Jennings et al., 2008)
Progenitor genotype
Cytology
Description

Amino acid replacement: M1I.

(Jennings et al., 2008)

Nucleotide substitution: G3A.

(Jennings et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:26,043,346..26,043,346 [+]
Nucleotide change:

G26043346A

Reported nucleotide change:

G3A

Amino acid change:

M1I | gro-PA; M1I | gro-PB; M1I | gro-PC; M1I | gro-PD; M1I | gro-PE; M1I | gro-PF; M1I | gro-PG; M1I | gro-PH; M1I | gro-PI; M1I | gro-PJ

Comment:

Initiator methionine codon mutated, so translation is instead initiated at the next in-frame start codon 58 codons downstream. Position of mutation on reference sequence inferred by FlyBase curator.

(Jennings et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant embryos have a neurogenic phenotype as judged by lack of embryonic cuticle.

      (Jennings et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      groMB12/gro[+] is a suppressor of eye phenotype of hryUAS.cIa

      (Jennings et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      groMB12 is rescued by gro+t10

      (Turki-Judeh and Courey, 2012)
      Partially rescued by

      groMB12 is partially rescued by groΔSP

      (Turki-Judeh and Courey, 2012)
      Not rescued by

      groMB12 is not rescued by groΔGP

      (Turki-Judeh and Courey, 2012)

      groMB12 is not rescued by groΔCcN

      (Turki-Judeh and Courey, 2012)
      Comments

      gro+t10 completely rescues the lethality of groMB12 homozygotes.

      groΔGP and groΔCcN each fail to rescue the lethality of groMB12 homozygotes.

      groΔSP partially rescues the lethality of groMB12 homozygotes.

      (Turki-Judeh and Courey, 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: A modifier of the eye phenotype caused by expression of hScer\UAS.cIa under the control of Scer\GAL4GMR.PF.

      (Jennings et al., 2008)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      groMB12
      (Turki-Judeh and Courey, 2012, Jennings et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)