FB2026_02 , released June 18, 2026
Allele: Dmel\Vps2PP6
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General Information
Symbol
Dmel\Vps2PP6
Species
D. melanogaster
Name
FlyBase ID
FBal0230476
Feature type
allele
Associated gene
Dmel\Vps2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Vaccari et al., 2009)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C?T.

(Vaccari et al., 2009)

Amino acid replacement: Q111term.

(Vaccari et al., 2009)

The premature stop codon is predicted to result in a truncated protein that lacks the C-terminal 145 amino acids of the wild-type product.

(Vaccari et al., 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:26,053,307..26,053,307 [+]
Nucleotide change:

C26053307T

Reported nucleotide change:

C?T

Amino acid change:

Q111term | Vps2-PA

Reported amino acid change:

Q111term

(Vaccari et al., 2009)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Compared with wild-type, egg chambers containing CG14542PP6 mutant cells exhibit a loss of plasma membrane, ultimately leading to the formation of clusters of multinucleated cells enclosed by a single actin cytoskeleton, with nuclei rested around clumps of actin-positive structures, possibly also membrane fragments.

      (Vaccari et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      The lethality of the Vps2PP6 FRT chromosome in the BDSC:39630 stock (w[*]; Vps2[PP6] P{ry[+t7.2]=neoFRT}82B/TM6B, Tb[1]) does not map to Vps2 : the Vps2PP6 FRT chromosome is viable over three deficiencies which delete Vps2 (Df(3R)ED6232, Df(3R)BSC751 and Df(3R)BSC140) and also complements the lethality of the Vps2CHf1 and Vps2CHf2 alleles.

      (Popodi et al., 2025.10.1)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      CG14542PP6
      Vps2PP6
      (Popodi et al., 2025.10.1)
      vps2PP6
      (Vaccari et al., 2009)
      vps2pp6
      (Lin et al., 2021, Wang et al., 2021)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)