FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\HtrA2+t2.5
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General Information
Symbol
Dmel\HtrA2+t2.5
Species
D. melanogaster
Name
FlyBase ID
FBal0230524
Feature type
allele
Associated gene
Dmel\HtrA2
Associated Insertion(s)
Carried in Construct
P{HtrA2+t2.5}
Key Links
Genomic Maps

Transgenic product class
genomic_DNA
(Tain et al., 2009)
wild_type
(Tain et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Tain et al., 2009)
wild_type
(Tain et al., 2009)
Mutagen
in vitro construct
(Tain et al., 2009)
Progenitor genotype
Carried in construct
P{HtrA2+t2.5}
Cytology
Description

2.5kb genomic fragment containing the predicted full-length HtrA2 gene, 700bp of upstream promoter region and the complete 3'UTR.

(Tain et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
HtrA2
Encoded product / tool
HtrA2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
rescue_region
3R:14,509,892..14,512,392 [-]
Comment:

Extent of rescue fragment determined from primer sequences.

(Tain et al., 2009)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      HtrA2+t2.5 rescues HtrA2Δ1

      (Yacobi-Sharon et al., 2013)

      HtrA2+t2.5 rescues HtrA2Δ1

      (Tain et al., 2009)
      Partially rescues

      HtrA2+t2.5 partially rescues HtrA2IFD/Df(3R)HtrA2Df1

      (Yacobi-Sharon et al., 2013)
      Comments

      Expression of two copies of HtrA2+t2.5 partially rescues the spermatogonial cyst death seen in HtrA2IFD/Df(3R)HtrA2Df1 mutant flies. The amount of germline cell death is restored to approximately 80% of wild type levels.

      Expression of two copies of HtrA2+t2.5 rescues the germline cell death seen in the spermatogonial cysts of HtrA2Δ1 mutant flies. The levels of germline cell death in these flies are approximately 120% of wild type levels.

      (Yacobi-Sharon et al., 2013)

      HtrA2+t2.5 rescues the defects of HtrA2Δ1 animals (from Df(3R)HtrA2Δ1 homozygotes in which the loss of mRpL11 function has been rescued by two copies of mRpL11+t2.0).

      (Tain et al., 2009)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      HtrA2+t2.5
      Name Synonyms
      Secondary FlyBase IDs
        References (3)