FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\HERC2KK100181
Open Close
General Information
Symbol
Dmel\HERC2KK100181
Species
D. melanogaster
Name
FlyBase ID
FBal0230609
Feature type
allele
Associated gene
Dmel\HERC2
Associated Insertion(s)
Carried in Construct
P{KK100181}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
in vitro construct
(Keleman et al., 2009.8.5)
Progenitor genotype
Carried in construct
P{KK100181}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK100181
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  neurofibromatosis
      modeled by Nf1E2
      (Walker et al., 2013)
      exacerbates  brain cancer
      modeled by Ras85DV12.cUa.UAS, scrib673
      (Manzanero-Ortiz et al., 2021)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Scer\GAL4Ras64B.PW/HERC2KK100181 is a suppressor of decreased body size | pupal stage phenotype of Nf1E2

      (Walker et al., 2013)
      NOT Suppressor of
      Statement
      Reference

      HERC2KK100181/Scer\GAL4C23 is a non-suppressor of decreased body size | pupal stage phenotype of Nf1E2

      (Walker et al., 2013)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of HERC2KK100181 under the control of Scer\GAL4Ras64B.PW suppresses the reduced pupal length phenotype seen in Nf1E2 animals, while expression under the control of either Scer\GAL4C23 or Scer\GAL4C23 has no significant effect.

      (Walker et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      HERC2KK100181
      Name Synonyms
      Secondary FlyBase IDs
        References (4)