FlyBase Allele Report: Dmel\Shal[KK100264]

General Information

Symbol

Dmel\Shal^KK100264

Species

D. melanogaster

Name

FlyBase ID

FBal0230644

Feature type

allele

Associated gene

Dmel\Shal

Associated Insertion(s)

Carried in Construct

P{KK100264}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK100264}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK100264

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Al-Ramahi et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult brain, with Scer\GAL4^elav-C155

(Hsiao et al., 2025)

interommatidial bristle | adult stage, with Scer\GAL4^GMR.PFa

(Hsiao et al., 2025)

ommatidium | adult stage, with Scer\GAL4^GMR.PFa

(Hsiao et al., 2025)

Detailed Description

Statement

Reference

Flies with expression of Shal^KK100264 driven by Scer\GAL4^GMR23E10 sleep similar amounts to parental controls.

(Pimentel et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^elav-C155, Shal^KK100264 has decreased rate of adult locomotory behavior phenotype, suppressible by Hsap\KCND3^UAS.Tag:MYC, Scer\GAL4^elav-C155

(Hsiao et al., 2025)

Scer\GAL4^GMR.PFa, Shal^KK100264 has visible | adult stage | progressive phenotype, suppressible by Hsap\KCND3^UAS.Tag:MYC, Scer\GAL4^GMR.PFa

(Hsiao et al., 2025)

Scer\GAL4^GMR.PFa, Shal^KK100264 has abnormal neuroanatomy | adult stage | progressive phenotype, suppressible by Hsap\KCND3^UAS.Tag:MYC, Scer\GAL4^GMR.PFa

(Hsiao et al., 2025)

Scer\GAL4^elav-C155, Shal^KK100264 has decreased size | adult stage phenotype, suppressible by Hsap\KCND3^UAS.Tag:MYC, Scer\GAL4^elav-C155

(Hsiao et al., 2025)

NOT suppressed by

Statement

Reference

Scer\GAL4^elav-C155, Shal^KK100264 has decreased size | adult stage phenotype, non-suppressible by Hsap\KCND3^UAS.Tag:MYC/Hsap\KCNA1^UAS.Tag:HA, Scer\GAL4^elav-C155

(Hsiao et al., 2025)

Scer\GAL4^elav-C155, Shal^KK100264 has decreased size | adult stage phenotype, non-suppressible by Hsap\KCNA1^UAS.Tag:HA, Scer\GAL4^elav-C155

(Hsiao et al., 2025)

Scer\GAL4^elav-C155, Shal^KK100264 has decreased rate of adult locomotory behavior phenotype, non-suppressible by Hsap\KCNA1^UAS.Tag:HA, Scer\GAL4^elav-C155

(Hsiao et al., 2025)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^elav-C155, Shal^KK100264 has adult brain phenotype, suppressible by Hsap\KCND3^UAS.Tag:MYC, Scer\GAL4^elav-C155

(Hsiao et al., 2025)

Scer\GAL4^GMR.PFa, Shal^KK100264 has ommatidium | adult stage phenotype, suppressible by Hsap\KCND3^UAS.Tag:MYC, Scer\GAL4^GMR.PFa

(Hsiao et al., 2025)

Scer\GAL4^GMR.PFa, Shal^KK100264 has interommatidial bristle | adult stage phenotype, suppressible by Hsap\KCND3^UAS.Tag:MYC, Scer\GAL4^GMR.PFa

(Hsiao et al., 2025)

NOT suppressed by

Statement

Reference

Scer\GAL4^elav-C155, Shal^KK100264 has adult brain phenotype, non-suppressible by Hsap\KCNA1^UAS.Tag:HA, Scer\GAL4^elav-C155

(Hsiao et al., 2025)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v103363

P{KK100264}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Shal^KK100264

(Al-Ramahi et al., 2018)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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