FB2026_02 , released June 18, 2026
Allele: Dmel\kat80KK100477
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General Information
Symbol
Dmel\kat80KK100477
Species
D. melanogaster
Name
FlyBase ID
FBal0230776
Feature type
allele
Associated gene
Dmel\kat80
Associated Insertion(s)
Carried in Construct
P{KK100477}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
in vitro construct
(Keleman et al., 2009.8.5)
Progenitor genotype
Carried in construct
P{KK100477}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK100477
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  microcephaly
      CEA
      (Mishra-Gorur et al., 2014)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of kat80KK100477 under the control of Scer\GAL4Vm26Aa.F results in moderate dorsal appendage defects in 31% of cases and strong defects in 9% of cases, with the appendages being rough and broad.

      Expression of kat80KK100477 under the control of Scer\GAL4CY2 results in moderate dorsal appendage defects in 52% of cases and strong defects in 5% of cases, with the appendages being rough and broad.

      (Peters et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Scer\GAL4Vm26Aa.F, kat80KK100477 has dorsal appendage phenotype, enhanceable by ttk[+]/ttktwp

      (Peters et al., 2013)

      Scer\GAL4CY2, kat80KK100477 has dorsal appendage phenotype, enhanceable by ttk[+]/ttktwp

      (Peters et al., 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The severity of the dorsal appendage defects caused by expression of kat80KK100477 under the control of either Scer\GAL4Vm26Aa.F or Scer\GAL4CY2 is enhanced by ttktwp/+.

      (Peters et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      kat80KK100477
      Name Synonyms
      Secondary FlyBase IDs
        References (3)