FlyBase Allele Report: Dmel\Agbe[KK100721]

General Information

Symbol

Dmel\Agbe^KK100721

Species

D. melanogaster

Name

FlyBase ID

FBal0230891

Feature type

allele

Associated gene

Dmel\Agbe

Associated Insertion(s)

Carried in Construct

P{KK100721}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK100721}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK100721

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of porphyria

CEA

(Huynh et al., 2019)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of porphyria

is ameliorated by Hsap\IREB2^UAS.Tag:FLAG

(Huynh et al., 2019)

is ameliorated by Irp-1A^UAS.cHa

(Huynh et al., 2019)

is ameliorated by Hsap\ACO1^UAS.Tag:FLAG

(Huynh et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate, with Scer\GAL4^phtm.PO

(Soltani et al., 2025)

increased size | third instar larval stage, with Scer\GAL4^phtm.PO

(Huynh et al., 2019)

lethal - all die before end of first instar larval stage, with Scer\GAL4^αTub84B.PL

(Huynh et al., 2019)

partially lethal - majority die, with Scer\GAL4^phtm.PO

(Huynh et al., 2019)

Phenotype Manifest In

ring gland | third instar larval stage, with Scer\GAL4^phtm.PO

(Huynh et al., 2019)

Detailed Description

Statement

Reference

The expression of AGBE^KK100721 under the control of Scer\GAL4^phm.PO leads to an enlarged ring gland in third instar larvae, which is red-brownish in brightfield and red auto-fluorescent to UV.

(Huynh et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Agbe^KK100721, Scer\GAL4^phtm.PO has abnormal developmental rate phenotype, enhanceable by Mco4^KO

(Soltani et al., 2025)

Suppressed by

Statement

Reference

Agbe^KK100721, Scer\GAL4^phtm.PO has increased size | third instar larval stage phenotype, suppressible by Hsap\ACO1^UAS.Tag:FLAG, Scer\GAL4^phtm.PO

(Huynh et al., 2019)

Agbe^KK100721, Scer\GAL4^phtm.PO has increased size | third instar larval stage phenotype, suppressible by Hsap\IREB2^UAS.Tag:FLAG, Scer\GAL4^phtm.PO

(Huynh et al., 2019)

Agbe^KK100721, Scer\GAL4^phtm.PO has increased size | third instar larval stage phenotype, suppressible by Irp-1A^UAS.cHa, Scer\GAL4^phtm.PO

(Huynh et al., 2019)

NOT suppressed by

Statement

Reference

Agbe^KK100721, Scer\GAL4^phtm.PO has increased size | third instar larval stage phenotype, non-suppressible by Irp-1A^C450S.UAS, Scer\GAL4^phtm.PO

(Huynh et al., 2019)

Agbe^KK100721, Scer\GAL4^phtm.PO has increased size | third instar larval stage phenotype, non-suppressible by Scer\ACO1^UAS.cHa, Scer\GAL4^phtm.PO

(Huynh et al., 2019)

Agbe^KK100721, Scer\GAL4^phtm.PO has increased size | third instar larval stage phenotype, non-suppressible by Scer\ACO1^ΔSp.UAS, Scer\GAL4^phtm.PO

(Huynh et al., 2019)

Phenotype Manifest In

Suppressed by

Statement

Reference

Agbe^KK100721, Scer\GAL4^phtm.PO has ring gland | somatic clone | third instar larval stage phenotype, suppressible by Irp-1A^UAS.cHa, Scer\GAL4^phtm.PO

(Huynh et al., 2019)

Agbe^KK100721, Scer\GAL4^phtm.PO has ring gland | somatic clone | third instar larval stage phenotype, suppressible by Hsap\ACO1^UAS.Tag:FLAG, Scer\GAL4^phtm.PO

(Huynh et al., 2019)

Agbe^KK100721, Scer\GAL4^phtm.PO has ring gland | somatic clone | third instar larval stage phenotype, suppressible by Hsap\IREB2^UAS.Tag:FLAG, Scer\GAL4^phtm.PO

(Huynh et al., 2019)

NOT suppressed by

Statement

Reference

Agbe^KK100721, Scer\GAL4^phtm.PO has ring gland | somatic clone | third instar larval stage phenotype, non-suppressible by Irp-1A^C450S.UAS, Scer\GAL4^phtm.PO

(Huynh et al., 2019)

Agbe^KK100721, Scer\GAL4^phtm.PO has ring gland | somatic clone | third instar larval stage phenotype, non-suppressible by Scer\ACO1^UAS.cHa, Scer\GAL4^phtm.PO

(Huynh et al., 2019)

Agbe^KK100721, Scer\GAL4^phtm.PO has ring gland | somatic clone | third instar larval stage phenotype, non-suppressible by Scer\ACO1^ΔSp.UAS, Scer\GAL4^phtm.PO

(Huynh et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v108087

P{KK100721}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

AGBE^KK100721

Agbe^KK100721

CG33138^KK100721

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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