FlyBase Allele Report: Dmel\Irp-1A[C450S.UAS]

General Information

Symbol

Dmel\Irp-1A^C450S.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0360855

Feature type

allele

Associated gene

Dmel\Irp-1A

Associated Insertion(s)

Carried in Construct

P{UAS-Irp-1A.C450S}

Key Links

Transgenic product class

missense_variant

(Huynh et al., 2019)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Huynh et al., 2019)

Mutagen

in vitro construct

(Huynh et al., 2019)

Progenitor genotype

Carried in construct

P{UAS-Irp-1A.C450S}

Cytology

Description

UAS regulatory sequences drive expression of a Irp-1A cDNA (LD36161 clone) that has been mutated to carry a C450S amino acid replacement (this mutation is predicted to abolish aconitase function and render the protein constitutively RNA-binding).

(Huynh et al., 2019)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Irp-1A

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable, with Scer\GAL4^phtm.PO

(Huynh et al., 2019)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Irp-1A^C450S.UAS, Scer\GAL4^phtm.PO is a suppressor of lethal - all die before end of P-stage | somatic clone phenotype of Nos^RNAi.UAS.cCa, Scer\GAL4^phtm.PO

(Huynh et al., 2019)

NOT Suppressor of

Statement

Reference

Scer\GAL4^phtm.PO/Irp-1A^C450S.UAS is a non-suppressor of lethal - all die before end of P-stage | somatic clone phenotype of Agbe^FCF-

(Huynh et al., 2019)

Irp-1A^C450S.UAS, Scer\GAL4^phtm.PO is a non-suppressor of increased size | third instar larval stage phenotype of Agbe^KK100721, Scer\GAL4^phtm.PO

(Huynh et al., 2019)

Phenotype Manifest In

Suppressor of

Statement

Reference

Irp-1A^C450S.UAS, Scer\GAL4^phtm.PO is a suppressor of ring gland | somatic clone | third instar larval stage phenotype of Nos^RNAi.UAS.cCa, Scer\GAL4^phtm.PO

(Huynh et al., 2019)

NOT Suppressor of

Statement

Reference

Irp-1A^C450S.UAS, Scer\GAL4^phtm.PO is a non-suppressor of ring gland | somatic clone | third instar larval stage phenotype of Agbe^KK100721, Scer\GAL4^phtm.PO

(Huynh et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Irp-1A^C450S.UAS

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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