FlyBase Allele Report: Dmel\spdi[KK101059]

General Information

Symbol

Dmel\spdi^KK101059

Species

D. melanogaster

Name

FlyBase ID

FBal0231045

Feature type

allele

Associated gene

Dmel\spdi

Associated Insertion(s)

Carried in Construct

P{KK101059}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK101059}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK101059

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

flightless, with Scer\GAL4^A9

(Saadi et al., 2011)

flightless, with Scer\GAL4^da.G32

(Saadi et al., 2011)

partially lethal - majority die, with Scer\GAL4^da.G32

(Saadi et al., 2011)

some die during pharate adult stage, with Scer\GAL4^da.G32

(Saadi et al., 2011)

sterile, with Scer\GAL4^da.G32

(Saadi et al., 2011)

Phenotype Manifest In

mesonotum, with Scer\GAL4^A9

(Saadi et al., 2011)

proboscis, with Scer\GAL4^da.G32

(Saadi et al., 2011)

wing, with Scer\GAL4^A9

(Saadi et al., 2011)

wing, with Scer\GAL4^da.G32

(Saadi et al., 2011)

Detailed Description

Statement

Reference

A small number of severely affected flies fail to eclose and die as pharate adults when CG13366^KK101059 is expressed using Scer\GAL4^da.G32. Eclosing flies are infertile and flightless and have a range of wing defects including inflated, crumpled or blistered wings. These flies die 2-3 days after eclosion as a result of distal proboscis defects and feeding difficulties.

Expression of CG13366^KK101059 using Scer\GAL4^A9 gives rise to flightless flies: approximately 70% have partially or completely uninflated, crumpled wings and the remaining 30% exhibit wings that are 'held out' and have blisters. Among flies with uninflated, crumpled wings, 70% also have a mild cleft dorsum.

(Saadi et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v108092

P{KK101059}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG13366^KK101059

spdi^KK101059

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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