FlyBase Allele Report: Dmel\pont[KK101103]

General Information

Symbol

Dmel\pont^KK101103

Species

D. melanogaster

Name

FlyBase ID

FBal0231064

Feature type

allele

Associated gene

Dmel\pont

Associated Insertion(s)

Carried in Construct

P{KK101103}

Also Known As

PONTIN RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK101103}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK101103

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates acute myeloid leukemia

modeled by Hsap\RUNX1::Hsap\RUNX1T1^UAS.cMa

(Breig et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of pont^KK101103 under the control of Scer\GAL4^Tub.PU from larval hatching onwards leads to defects in third instar salivary gland polytene chromosomes (smaller and with a thin and disorganized structure).

(Prozzillo et al., 2021)

Expressing pont^KK101103 under the control of Scer\GAL4^VP16.bam results in immotile sperm.

(Zur Lage et al., 2019)

Testes in individuals expressing pont^KK101103 under the control of Scer\GAL4^VP16.bam lack motile sperm despite sperm bundles being largely normal, as compared to controls.

(Zur Lage et al., 2018)

The expression of pont^KK101103 under the control of Scer\GAL4^c564 leads to lethality.

(Kumar et al., 2016)

Expression of pont^KK101103 under the control of Scer\GAL4^lz-gal4 has no effect on lz-positive hematopoietic cell number or their differentiation into crystal cells.

(Breig et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

pont^KK101103, Scer\GAL4^lz-gal4 is a suppressor of lethal - all die before end of pupal stage phenotype of Hsap\RUNX1::Hsap\RUNX1T1^UAS.cMa, Scer\GAL4^lz-gal4

(Breig et al., 2014)

Phenotype Manifest In

Suppressor of

Statement

Reference

pont^KK101103, Scer\GAL4^lz-gal4 is a suppressor of embryonic/larval hemocyte | increased number | larval stage phenotype of Hsap\RUNX1::Hsap\RUNX1T1^UAS.cMa, Scer\GAL4^lz-gal4

(Breig et al., 2014)

pont^KK101103, Scer\GAL4^lz-gal4 is a suppressor of embryonic/larval crystal cell | larval stage phenotype of Hsap\RUNX1::Hsap\RUNX1T1^UAS.cMa, Scer\GAL4^lz-gal4

(Breig et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of pont^KK101103 suppresses the lethality seen when Hsap\RUNX1::Hsap\RUNX1T1^UAS.cMa is expressed under the control of Scer\GAL4^lz-gal4. The increase in lz positive larval hematopoietic cells is suppressed and differentiation into crystal cells is partially restored.

(Breig et al., 2014)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v105408

P{KK101103}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

dPontin^KK101103

(Bailetti et al., 2019)

pont^KK101103

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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