FlyBase Allele Report: Dmel\shn[KK101278]

General Information

Symbol

Dmel\shn^KK101278

Species

D. melanogaster

Name

FlyBase ID

FBal0231168

Feature type

allele

Associated gene

Dmel\shn

Associated Insertion(s)

Carried in Construct

P{KK101278}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK101278}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK101278

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of juvenile polyposis syndrome

CEA

(Zhou et al., 2021, Zhou and Boutros, 2020)

CEA with puc^E69

(Zhou et al., 2021)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of juvenile polyposis syndrome

is ameliorated by BacA\p35^lexAop.cEa

(Zhou et al., 2021)

is ameliorated by hid^Pe05016

(Zhou et al., 2021)

is exacerbated by puc^E69

(Zhou et al., 2021, Zhou and Boutros, 2020)

is ameliorated by bsk^DN.UAS

(Zhou and Boutros, 2020)

is ameliorated by kay^RNAi.UAS

(Zhou and Boutros, 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage, with Scer\GAL4^ple.PF

(Robles-Murguia et al., 2020)

abnormal neuroanatomy, with Scer\GAL4²²¹

(Iyer et al., 2013)

abnormal neuroanatomy, with Scer\GAL4^ppk.1.9

(Iyer et al., 2013)

abnormal proboscis extension reflex, with Scer\GAL4^ple.PF

(Robles-Murguia et al., 2020)

Phenotype Manifest In

abdominal anterior ventral multidendritic neuron vdaa, with Scer\GAL4^ppk.1.9

(Iyer et al., 2013)

larval dorsal multidendritic neuron ddaC, with Scer\GAL4^ppk.1.9

(Iyer et al., 2013)

larval dorsal multidendritic neuron ddaD, with Scer\GAL4²²¹

(Iyer et al., 2013)

Detailed Description

Statement

Reference

Expression of shn^KK101278 under the control of Scer\GAL4^ple.PF leads to an increase in the probability of proboscis extension reflex and (its expression (in combination with tub-Gal80[ts]) leads to an increase in the spontaneous locomotion particularly in proximity to the food when compared to control adults.

(Robles-Murguia et al., 2020)

Expression of shn^KK101278 under the control of Scer\GAL4^Bx-MS1096 has no effect on male wing size or patterning.

Expression of shn^KK101278 under the control of Scer\GAL4^Bx-MS1096 has no effect on female wing size or patterning.

(Schertel et al., 2015)

Expression of shn^KK101278 in C-I neurons under the control of Scer\GAL4²²¹ results in ddaD neurons that have an increased number of dendritic branches compared to controls.

Expression of shn^KK101278 in C-IV neurons under the control of shn^KK101278 results in a reduction in total dendritic length in ddaC and v'ada neurons. The total number of dendritic branches is also reduced in ddaC neurons.

(Iyer et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v105643

P{KK101278}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

shn^KK101278

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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