FlyBase Allele Report: Dmel\Rpn8[KK101319]

General Information

Symbol

Dmel\Rpn8^KK101319

Species

D. melanogaster

Name

FlyBase ID

FBal0231195

Feature type

allele

Associated gene

Dmel\Rpn8

Associated Insertion(s)

Carried in Construct

P{KK101319}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK101319}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK101319

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of congenital heart disease

CEA

(Nim et al., 2021)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | larval stage, with Scer\GAL4^sqh.PW

(Tsou et al., 2012)

lethal | pharate adult stage, with Scer\GAL4^elav.PU

(Tsou et al., 2012)

lethal | pupal stage, with Scer\GAL4^elav.PU

(Tsou et al., 2012)

lethal | pupal stage, with Scer\GAL4^sqh.PW

(Tsou et al., 2012)

lethal - all die before end of pupal stage, with Scer\GAL4^dpp.PU

(Zhang et al., 2012)

some die during pupal stage, with Scer\GAL4^dpp.PU

(Zhang et al., 2012)

visible, with Scer\GAL4^bbg-C96

(Zhang et al., 2012, Zhang et al., 2012)

Phenotype Manifest In

wing, with Scer\GAL4^bbg-C96

(Zhang et al., 2012, Zhang et al., 2012)

Detailed Description

Statement

Reference

Expression of Mov34^KK101319 using a relatively weak Scer\GAL4^elav.PU causes adults to die soon after eclosion.

(Tsou et al., 2012)

Expression of Rpn8^KK101319 under the control of Scer\GAL4^bbg-C96 results in notched wings.

(Zhang et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Rpn8^KK101319, Scer\GAL4^GMR.long is a non-enhancer of visible phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long

(Tsou et al., 2015)

NOT Suppressor of

Statement

Reference

Rpn8^KK101319, Scer\GAL4^GMR.long is a non-suppressor of visible phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Rpn8^KK101319, Scer\GAL4^GMR.long is a non-enhancer of eye phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long

(Tsou et al., 2015)

NOT Suppressor of

Statement

Reference

Rpn8^KK101319, Scer\GAL4^GMR.long is a non-suppressor of eye phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of Rpn8^KK101319 does not suppress the protective role of expression of Hsap\ATXN3^{Scer\UAS.WT.T:Zzzz\His6} or DnaJ-1^Scer\UAS.cKa in suppression of eye degeneration in Scer\GAL4^GMR.long>Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} flies. Co-expression of Rpn8^KK101319 does not alter eye degeneration in Scer\GAL4^GMR.long>Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} flies.

(Tsou et al., 2015)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v108573

P{KK101319}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Mov34^KK101319

Rpn8¹⁰⁸⁵⁷³

(Nim et al., 2021)

Rpn8^KK101319

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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