FlyBase Allele Report: Dmel\CycA[KK101548]

General Information

Symbol

Dmel\CycA^KK101548

Species

D. melanogaster

Name

FlyBase ID

FBal0231340

Feature type

allele

Associated gene

Dmel\CycA

Associated Insertion(s)

Carried in Construct

P{KK101548}

Also Known As

UAS-CycA^RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK101548}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK101548

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal meiotic cell cycle, with Scer\GAL4^VP16.bam

(Varadarajan et al., 2016)

Phenotype Manifest In

larval outer optic anlage, with Scer\GAL4^c768

(Zhou and Luo, 2013)

spermatocyte, with Scer\GAL4^VP16.bam

(Varadarajan et al., 2016)

Detailed Description

Statement

Reference

Expression of CycA^KK101548 under the control of Scer\GAL4^{bam.T:Hsim\VP16} prevents meiosis I progression in adult males: spermatocytes only progress as far as metaphase-anaphase I before differentiating into aberrant 16-cell onion-stage spermatids.

(Varadarajan et al., 2016)

Expression of CycA^KK101548 under the control of Scer\GAL4^c768 results defects in maintenance of the neuroepithelium cells in the developing optic lobe and premature neuroblast formation.

(Zhou and Luo, 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Scer\GAL4^VP16.bam/CycA^KK101548 is a non-suppressor of male sterile | recessive phenotype of Myt1¹

(Varadarajan et al., 2016)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^VP16.bam/CycA^KK101548 is a suppressor of fusome | male | adult stage phenotype of Myt1¹

(Varadarajan et al., 2016)

Scer\GAL4^VP16.bam/CycA^KK101548 is a suppressor of centriole | male | adult stage phenotype of Myt1¹

(Varadarajan et al., 2016)

Scer\GAL4^VP16.bam/CycA^KK101548 is a suppressor of meiotic spindle | male | adult stage phenotype of Myt1¹

(Varadarajan et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of CycA^KK101548 under the control of Scer\GAL4^{bam.T:Hsim\VP16} in the Myt1¹ homozygote mutant background partially rescues the fusome defects as well as the premature centriole disengagement and multipolar meiotic spindle defects characteristic for Myt1¹ mutants but fails to restore the male sterility.

(Varadarajan et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v103595

P{KK101548}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CycA^KK101548

CycA^siRNA

(Varadarajan et al., 2016)

cycA^RNAi-95

(Vasavan et al., 2024)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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